Mutations of TFPI-binding exosites on factor VII cause bleeding phenotypes in factor VII deficiency

Tissue factor (TF) pathway inhibitor (TFPI) is a Kunitz-type anticoagulation protein that inhibits activated factor VII (FVIIa)/TF complex. Incidentally, many different F7 gene variants, including TFPI-binding exosite mutations, have been reported in patients with congenital FVII deficiency and clin...

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Detalles Bibliográficos
Autores principales: Seanoon, Karnsasin, Payongsri, Panwajee, Vivithanaporn, Pornpun, Sirachainan, Nongnuch, Chuansumrit, Ampaiwan, Hongeng, Suradej, Tanratana, Pansakorn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2022
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661381/
https://www.ncbi.nlm.nih.gov/pubmed/35973191
http://dx.doi.org/10.1182/bloodadvances.2022007560

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