Systemic Nos2 Depletion and Cox inhibition limits TNBC disease progression and alters lymphoid cell spatial orientation and density

Antitumor immune polarization is a key predictor of clinical outcomes to cancer therapy. An emerging concept influencing clinical outcome involves the spatial location of CD8(+) T cells, within the tumor. Our earlier work demonstrated immunosuppressive effects of NOS2 and COX2 tumor expression. Here...

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Detalles Bibliográficos
Autores principales: Somasundaram, Veena, Ridnour, Lisa A., Cheng, Robert YS., Walke, Abigail J., Kedei, Noemi, Bhattacharyya, Dibyangana D., Wink, Adelaide L., Edmondson, Elijah F., Butcher, Donna, Warner, Andrew C., Dorsey, Tiffany H., Scheiblin, David A., Heinz, William, Bryant, Richard J., Kinders, Robert J., Lipkowitz, Stanley, Wong, Stephen TC., Pore, Milind, Hewitt, Stephen M., McVicar, Daniel W., Anderson, Stephen K., Chang, Jenny, Glynn, Sharon A., Ambs, Stefan, Lockett, Stephen J., Wink, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661390/
https://www.ncbi.nlm.nih.gov/pubmed/36375380
http://dx.doi.org/10.1016/j.redox.2022.102529

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