New functions of C3G in platelet biology: Contribution to ischemia-induced angiogenesis, tumor metastasis and TPO clearance

C3G is a Rap1 guanine nucleotide exchange factor that controls platelet activation, aggregation, and the release of α-granule content. Transgenic expression of C3G in platelets produces a net proangiogenic secretome through the retention of thrombospondin-1. In a physiological context, C3G also prom...

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Detalles Bibliográficos
Autores principales: Hernández-Cano, Luis, Fernández-Infante, Cristina, Herranz, Óscar, Berrocal, Pablo, Lozano, Francisco S., Sánchez-Martín, Manuel A., Porras, Almudena, Guerrero, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661425/
https://www.ncbi.nlm.nih.gov/pubmed/36393850
http://dx.doi.org/10.3389/fcell.2022.1026287

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661425/
https://www.ncbi.nlm.nih.gov/pubmed/36393850
http://dx.doi.org/10.3389/fcell.2022.1026287

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