Discovery of BT8009: A Nectin-4 Targeting Bicycle Toxin Conjugate for the Treatment of Cancer

[Image: see text] Bicycle toxin conjugates (BTCs) are a promising new class of molecules for targeted delivery of toxin payloads into tumors. Herein we describe the discovery of BT8009, a Nectin-4 targeting BTC currently under clinical evaluation. Nectin-4 is overexpressed in multiple tumor types an...

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Detalles Bibliográficos
Autores principales: Mudd, Gemma E., Scott, Heather, Chen, Liuhong, van Rietschoten, Katerine, Ivanova-Berndt, Gabriela, Dzionek, Katarzyna, Brown, Amy, Watcham, Sophie, White, Lewi, Park, Peter U., Jeffrey, Phil, Rigby, Mike, Beswick, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661471/
https://www.ncbi.nlm.nih.gov/pubmed/36204777
http://dx.doi.org/10.1021/acs.jmedchem.2c00065

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