Small Molecule Inhibitors of Lymphocyte Perforin as Focused Immunosuppressants for Infection and Autoimmunity

[Image: see text] New drugs that precisely target the immune mechanisms critical for cytotoxic T lymphocyte (CTL) and natural killer (NK) cell driven pathologies are desperately needed. In this perspective, we explore the cytolytic protein perforin as a target for therapeutic intervention. Perforin...

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Detalles Bibliográficos
Autores principales: Spicer, Julie A., Huttunen, Kristiina M., Jose, Jiney, Dimitrov, Ivo, Akhlaghi, Hedieh, Sutton, Vivien R., Voskoboinik, Ilia, Trapani, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661472/
https://www.ncbi.nlm.nih.gov/pubmed/36263926
http://dx.doi.org/10.1021/acs.jmedchem.2c01338

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661472/
https://www.ncbi.nlm.nih.gov/pubmed/36263926
http://dx.doi.org/10.1021/acs.jmedchem.2c01338

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