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Development of a Highly Potent Transthyretin Amyloidogenesis Inhibitor: Design, Synthesis, and Evaluation

[Image: see text] Transthyretin amyloidosis (ATTR) is a group of fatal diseases described by the misfolding and amyloid deposition of transthyretin (TTR). Discovering small molecules that bind and stabilize the TTR tetramer, preventing its dissociation and subsequent aggregation, is a therapeutic st...

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Detalles Bibliográficos
Autores principales:	Pinheiro, Francisca, Pallarès, Irantzu, Peccati, Francesca, Sánchez-Morales, Adrià, Varejão, Nathalia, Bezerra, Filipa, Ortega-Alarcon, David, Gonzalez, Danilo, Osorio, Marcelo, Navarro, Susanna, Velázquez-Campoy, Adrián, Almeida, Maria Rosário, Reverter, David, Busqué, Félix, Alibés, Ramon, Sodupe, Mariona, Ventura, Salvador
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661476/ https://www.ncbi.nlm.nih.gov/pubmed/36306808 http://dx.doi.org/10.1021/acs.jmedchem.2c01195

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