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Discovery and Structure–Activity Relationship Studies of Novel Adenosine A(1) Receptor-Selective Agonists

[Image: see text] A series of benzyloxy and phenoxy derivatives of the adenosine receptor agonists N(6)-cyclopentyl adenosine (CPA) and N(6)-cyclopentyl 5′-N-ethylcarboxamidoadenosine (CP-NECA) were synthesized, and their potency and selectivity were assessed. We observed that the most potent were t...

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Detalles Bibliográficos
Autores principales:	Preti, Barbara, Suchankova, Anna, Deganutti, Giuseppe, Leuenberger, Michele, Barkan, Kerry, Manulak, Iga, Huang, Xianglin, Carvalho, Sabrina, Ladds, Graham, Lochner, Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661479/ https://www.ncbi.nlm.nih.gov/pubmed/36270633 http://dx.doi.org/10.1021/acs.jmedchem.2c01414

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