Co-transducing B7H3 CAR-NK cells with the DNR preserves their cytolytic function against GBM in the presence of exogenous TGF-β

Cord blood (CB)-derived natural killer (NK) cells that are genetically engineered to express a chimeric antigen receptor (CAR) are an attractive off-the-shelf therapy for the treatment of cancer, demonstrating a robust safety profile in vivo. For poor prognosis brain tumors such as glioblastoma mult...

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Detalles Bibliográficos
Autores principales: Chaudhry, Kajal, Geiger, Ashley, Dowlati, Ehsan, Lang, Haili, Sohai, Danielle K., Hwang, Eugene I., Lazarski, Christopher A., Yvon, Eric, Holdhoff, Matthias, Jones, Richard, Savoldo, Barbara, Cruz, Conrad Russell Y., Bollard, Catherine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661497/
https://www.ncbi.nlm.nih.gov/pubmed/36381305
http://dx.doi.org/10.1016/j.omtm.2022.10.010

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