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Clinical manifestations of alopecia in autoimmune blistering diseases: A cross-sectional study

BACKGROUND: Alopecia is a complication of autoimmune blistering diseases (AIBDs) that affects patients’ quality of life; however, it has generally been overlooked in patients with severe disease because it is regarded as a cosmetic issue. OBJECTIVE: To study the epidemiologic data and clinical prese...

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Autores principales: Xie, Danica, Bilgic, Asli, Abu Alrub, Nada, Dicle, Özlem, Murrell, Dédée F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661710/
https://www.ncbi.nlm.nih.gov/pubmed/36387063
http://dx.doi.org/10.1016/j.jdin.2022.08.025
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author Xie, Danica
Bilgic, Asli
Abu Alrub, Nada
Dicle, Özlem
Murrell, Dédée F.
author_facet Xie, Danica
Bilgic, Asli
Abu Alrub, Nada
Dicle, Özlem
Murrell, Dédée F.
author_sort Xie, Danica
collection PubMed
description BACKGROUND: Alopecia is a complication of autoimmune blistering diseases (AIBDs) that affects patients’ quality of life; however, it has generally been overlooked in patients with severe disease because it is regarded as a cosmetic issue. OBJECTIVE: To study the epidemiologic data and clinical presentations of alopecia in our cohort of patients with AIBDs. METHODS: Forty-one patients with AIBDs were assessed in this cross-sectional study. An assessment tool to collate patient information, including AIBD scalp involvement, trichoscopic findings, and Severity of Alopecia Tool II scores, was used. RESULTS: More than 70% of patients in our cohort had at least 1 type of alopecia, with 10% presenting with a nonspecific (end-stage) scarring alopecia. Elevated Dsg1 ratios were predictive of hair loss in pemphigus vulgaris (P < .001) and increased alopecia was associated with worse disease severity in bullous pemphigoid (P = .001). LIMITATIONS: The small sample size and lack of severe cases. CONCLUSION: There is a likelihood that 1 in 10 patients with AIBDs have a scarring alopecia related to their disease. To our knowledge, this is the first study including alopecia prevalence in patients with bullous pemphigoid, which was not significantly increased despite providing clues to disease severity.
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spelling pubmed-96617102022-11-15 Clinical manifestations of alopecia in autoimmune blistering diseases: A cross-sectional study Xie, Danica Bilgic, Asli Abu Alrub, Nada Dicle, Özlem Murrell, Dédée F. JAAD Int Original Article BACKGROUND: Alopecia is a complication of autoimmune blistering diseases (AIBDs) that affects patients’ quality of life; however, it has generally been overlooked in patients with severe disease because it is regarded as a cosmetic issue. OBJECTIVE: To study the epidemiologic data and clinical presentations of alopecia in our cohort of patients with AIBDs. METHODS: Forty-one patients with AIBDs were assessed in this cross-sectional study. An assessment tool to collate patient information, including AIBD scalp involvement, trichoscopic findings, and Severity of Alopecia Tool II scores, was used. RESULTS: More than 70% of patients in our cohort had at least 1 type of alopecia, with 10% presenting with a nonspecific (end-stage) scarring alopecia. Elevated Dsg1 ratios were predictive of hair loss in pemphigus vulgaris (P < .001) and increased alopecia was associated with worse disease severity in bullous pemphigoid (P = .001). LIMITATIONS: The small sample size and lack of severe cases. CONCLUSION: There is a likelihood that 1 in 10 patients with AIBDs have a scarring alopecia related to their disease. To our knowledge, this is the first study including alopecia prevalence in patients with bullous pemphigoid, which was not significantly increased despite providing clues to disease severity. Elsevier 2022-10-11 /pmc/articles/PMC9661710/ /pubmed/36387063 http://dx.doi.org/10.1016/j.jdin.2022.08.025 Text en © 2022 Published by Elsevier Inc on behalf of the American Academy of Dermatology, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Xie, Danica
Bilgic, Asli
Abu Alrub, Nada
Dicle, Özlem
Murrell, Dédée F.
Clinical manifestations of alopecia in autoimmune blistering diseases: A cross-sectional study
title Clinical manifestations of alopecia in autoimmune blistering diseases: A cross-sectional study
title_full Clinical manifestations of alopecia in autoimmune blistering diseases: A cross-sectional study
title_fullStr Clinical manifestations of alopecia in autoimmune blistering diseases: A cross-sectional study
title_full_unstemmed Clinical manifestations of alopecia in autoimmune blistering diseases: A cross-sectional study
title_short Clinical manifestations of alopecia in autoimmune blistering diseases: A cross-sectional study
title_sort clinical manifestations of alopecia in autoimmune blistering diseases: a cross-sectional study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661710/
https://www.ncbi.nlm.nih.gov/pubmed/36387063
http://dx.doi.org/10.1016/j.jdin.2022.08.025
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