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Clinical manifestations of alopecia in autoimmune blistering diseases: A cross-sectional study
BACKGROUND: Alopecia is a complication of autoimmune blistering diseases (AIBDs) that affects patients’ quality of life; however, it has generally been overlooked in patients with severe disease because it is regarded as a cosmetic issue. OBJECTIVE: To study the epidemiologic data and clinical prese...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661710/ https://www.ncbi.nlm.nih.gov/pubmed/36387063 http://dx.doi.org/10.1016/j.jdin.2022.08.025 |
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author | Xie, Danica Bilgic, Asli Abu Alrub, Nada Dicle, Özlem Murrell, Dédée F. |
author_facet | Xie, Danica Bilgic, Asli Abu Alrub, Nada Dicle, Özlem Murrell, Dédée F. |
author_sort | Xie, Danica |
collection | PubMed |
description | BACKGROUND: Alopecia is a complication of autoimmune blistering diseases (AIBDs) that affects patients’ quality of life; however, it has generally been overlooked in patients with severe disease because it is regarded as a cosmetic issue. OBJECTIVE: To study the epidemiologic data and clinical presentations of alopecia in our cohort of patients with AIBDs. METHODS: Forty-one patients with AIBDs were assessed in this cross-sectional study. An assessment tool to collate patient information, including AIBD scalp involvement, trichoscopic findings, and Severity of Alopecia Tool II scores, was used. RESULTS: More than 70% of patients in our cohort had at least 1 type of alopecia, with 10% presenting with a nonspecific (end-stage) scarring alopecia. Elevated Dsg1 ratios were predictive of hair loss in pemphigus vulgaris (P < .001) and increased alopecia was associated with worse disease severity in bullous pemphigoid (P = .001). LIMITATIONS: The small sample size and lack of severe cases. CONCLUSION: There is a likelihood that 1 in 10 patients with AIBDs have a scarring alopecia related to their disease. To our knowledge, this is the first study including alopecia prevalence in patients with bullous pemphigoid, which was not significantly increased despite providing clues to disease severity. |
format | Online Article Text |
id | pubmed-9661710 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-96617102022-11-15 Clinical manifestations of alopecia in autoimmune blistering diseases: A cross-sectional study Xie, Danica Bilgic, Asli Abu Alrub, Nada Dicle, Özlem Murrell, Dédée F. JAAD Int Original Article BACKGROUND: Alopecia is a complication of autoimmune blistering diseases (AIBDs) that affects patients’ quality of life; however, it has generally been overlooked in patients with severe disease because it is regarded as a cosmetic issue. OBJECTIVE: To study the epidemiologic data and clinical presentations of alopecia in our cohort of patients with AIBDs. METHODS: Forty-one patients with AIBDs were assessed in this cross-sectional study. An assessment tool to collate patient information, including AIBD scalp involvement, trichoscopic findings, and Severity of Alopecia Tool II scores, was used. RESULTS: More than 70% of patients in our cohort had at least 1 type of alopecia, with 10% presenting with a nonspecific (end-stage) scarring alopecia. Elevated Dsg1 ratios were predictive of hair loss in pemphigus vulgaris (P < .001) and increased alopecia was associated with worse disease severity in bullous pemphigoid (P = .001). LIMITATIONS: The small sample size and lack of severe cases. CONCLUSION: There is a likelihood that 1 in 10 patients with AIBDs have a scarring alopecia related to their disease. To our knowledge, this is the first study including alopecia prevalence in patients with bullous pemphigoid, which was not significantly increased despite providing clues to disease severity. Elsevier 2022-10-11 /pmc/articles/PMC9661710/ /pubmed/36387063 http://dx.doi.org/10.1016/j.jdin.2022.08.025 Text en © 2022 Published by Elsevier Inc on behalf of the American Academy of Dermatology, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Xie, Danica Bilgic, Asli Abu Alrub, Nada Dicle, Özlem Murrell, Dédée F. Clinical manifestations of alopecia in autoimmune blistering diseases: A cross-sectional study |
title | Clinical manifestations of alopecia in autoimmune blistering diseases: A cross-sectional study |
title_full | Clinical manifestations of alopecia in autoimmune blistering diseases: A cross-sectional study |
title_fullStr | Clinical manifestations of alopecia in autoimmune blistering diseases: A cross-sectional study |
title_full_unstemmed | Clinical manifestations of alopecia in autoimmune blistering diseases: A cross-sectional study |
title_short | Clinical manifestations of alopecia in autoimmune blistering diseases: A cross-sectional study |
title_sort | clinical manifestations of alopecia in autoimmune blistering diseases: a cross-sectional study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661710/ https://www.ncbi.nlm.nih.gov/pubmed/36387063 http://dx.doi.org/10.1016/j.jdin.2022.08.025 |
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