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Angiotensin II receptor type 1 blockade regulates Klotho expression to induce TSC2-deficient cell death

Lymphangioleiomyomatosis (LAM) is a multisystem disease occurring in women of child-bearing age manifested by uncontrolled proliferation of smooth muscle–like “LAM” cells in the lungs. LAM cells bear loss-of-function mutations in tuberous sclerosis complex (TSC) genes TSC1 and/or TSC2, causing hyper...

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Detalles Bibliográficos
Autores principales:	Shrestha, Shikshya, Adib, Elio, Imani, Jewel, Aguiar, Dean J., Lamattina, Anthony M., Tassew, Dereje D., Henske, Elizabeth P., Perrella, Mark A., Priolo, Carmen, El-Chemaly, Souheil
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661712/ https://www.ncbi.nlm.nih.gov/pubmed/36220392 http://dx.doi.org/10.1016/j.jbc.2022.102580

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