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Structure of the drug target ClpC1 unfoldase in action provides insights on antibiotic mechanism of action

The unfoldase ClpC1 is one of the most exciting drug targets against tuberculosis. This AAA+ unfoldase works in cooperation with the ClpP1P2 protease and is the target of at least four natural product antibiotics: cyclomarin, ecumicin, lassomycin, and rufomycin. Although these molecules are promisin...

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Detalles Bibliográficos
Autores principales:	Weinhäupl, Katharina, Gragera, Marcos, Bueno-Carrasco, M. Teresa, Arranz, Rocío, Krandor, Olga, Akopian, Tatos, Soares, Raquel, Rubin, Eric, Felix, Jan, Fraga, Hugo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661721/ https://www.ncbi.nlm.nih.gov/pubmed/36208775 http://dx.doi.org/10.1016/j.jbc.2022.102553

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