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JAK1 inactivation promotes proliferation and migration of endometrial cancer cells via upregulating the hypoxia-inducible factor signaling pathway

BACKGROUND: Loss-of-function (LOF) mutations of JAK1, a member of the JAK kinase family, were frequently observed in EC, indicating that JAK1 may act as a tumor suppressor, at least in EC. However, the mechanism of JAK1 mediated regulation of tumorigenesis remains poorly understood. METHODS: The gen...

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Detalles Bibliográficos
Autores principales:	Lin, Qin, Chen, Zheng, Shi, Wei, Lv, Zeheng, Wan, Xiaoping, Gao, Kun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661757/ https://www.ncbi.nlm.nih.gov/pubmed/36376931 http://dx.doi.org/10.1186/s12964-022-00990-5

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