Implantable Electroceutical Approach Improves Myelination by Restoring Membrane Integrity in a Mouse Model of Peripheral Demyelinating Neuropathy (Adv. Sci. 32/2022)

Charcot‐Marie‐Tooth Disease Charcot‐Marie‐Tooth (CMT) disease – the most prevalent inherited peripheral neuropathy worldwide – currently lacks an approved treatment, as the biochemical interventions attempted have remained unsuccessful. In article number 2201358, Minseok S. Kim and co‐workers introd...

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Detalles Bibliográficos
Autores principales: Intisar, Aseer, Shin, Hyun Young, Kim, Woon‐Hae, Kang, Hyun Gyu, Kim, Min Young, Kim, Yu Seon, Cho, Youngjun, Mo, Yun Jeoung, Lim, Heejin, Lee, Sanghoon, Lu, Q. Richard, Lee, Yun‐Il, Kim, Minseok S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9661863/
http://dx.doi.org/10.1002/advs.202270208
Descripción
Sumario:Charcot‐Marie‐Tooth Disease Charcot‐Marie‐Tooth (CMT) disease – the most prevalent inherited peripheral neuropathy worldwide – currently lacks an approved treatment, as the biochemical interventions attempted have remained unsuccessful. In article number 2201358, Minseok S. Kim and co‐workers introduce a paradigm‐shifting biophysical treatment for CMT disease based on electroceuticals. The optimal electrical stimulation condition improves peripheral myelination by inducing a dynamic recovery in the distribution of key biomolecular constituents of myelin, thus restoring the myelin membrane integrity. [Image: see text]

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