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Depression, Diabetes Mellitus and Mortality in Older Adults: A National Cohort Study in Taiwan

PURPOSE: Diabetes mellitus (DM) increases the risk of cardiovascular and all-cause mortality. The coexistence of depression and DM is associated with an increased risk of DM complications and functional morbidity. The independent effect of depression on mortality in patients with DM is unclear, and...

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Autores principales: Chen, Vincent Chin-Hung, Wang, Tsu-Nai, Hsieh, Ming-Chia, Chou, Shih-Yong, Lee, Meng-Chih, McIntyre, Roger S, Lu, Mong-Liang, Liao, Yin-To, Yeh, Chih-Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9662019/
https://www.ncbi.nlm.nih.gov/pubmed/36387945
http://dx.doi.org/10.2147/NDT.S379174
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author Chen, Vincent Chin-Hung
Wang, Tsu-Nai
Hsieh, Ming-Chia
Chou, Shih-Yong
Lee, Meng-Chih
McIntyre, Roger S
Lu, Mong-Liang
Liao, Yin-To
Yeh, Chih-Jung
author_facet Chen, Vincent Chin-Hung
Wang, Tsu-Nai
Hsieh, Ming-Chia
Chou, Shih-Yong
Lee, Meng-Chih
McIntyre, Roger S
Lu, Mong-Liang
Liao, Yin-To
Yeh, Chih-Jung
author_sort Chen, Vincent Chin-Hung
collection PubMed
description PURPOSE: Diabetes mellitus (DM) increases the risk of cardiovascular and all-cause mortality. The coexistence of depression and DM is associated with an increased risk of DM complications and functional morbidity. The independent effect of depression on mortality in patients with DM is unclear, and relevant Asian studies have provided inconsistent results. Accordingly, this study assessed the independent and additive effects of DM and depression on mortality in a nationally representative cohort of older adults in Taiwan over a 10-year observation period. PATIENTS AND METHODS: A total of 5041 participants aged 50 years or older were observed between 1996 and 2007. We defined depression as a score of ≥8 on the 10-item Center for Epidemiologic Studies Depression (CES-D 10) scale. Additionally, we defined participants as having type 2 DM if they had received a diagnosis of type 2 DM from a health-care provider. Cox proportional hazard models were applied to analyze predictors of mortality in depression and DM comorbidity groups. RESULTS: During the 10-year follow-up period, 1637 deaths were documented. After adjustment for potential confounders, the hazard ratios for mortality in participants with both depression and DM, DM only, and depression only were 2.47 (95% confidence interval [CI]: 2.02–3.03), 1.95 (95% CI: 1.63–2.32), and 1.23 (95% CI: 1.09–1.39), respectively. CONCLUSION: The co-occurrence of depression with DM in Asian adults increased overall mortality rates. Our results indicate that the increased mortality hazard in individuals with DM and depression was independent of sex.
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spelling pubmed-96620192022-11-15 Depression, Diabetes Mellitus and Mortality in Older Adults: A National Cohort Study in Taiwan Chen, Vincent Chin-Hung Wang, Tsu-Nai Hsieh, Ming-Chia Chou, Shih-Yong Lee, Meng-Chih McIntyre, Roger S Lu, Mong-Liang Liao, Yin-To Yeh, Chih-Jung Neuropsychiatr Dis Treat Original Research PURPOSE: Diabetes mellitus (DM) increases the risk of cardiovascular and all-cause mortality. The coexistence of depression and DM is associated with an increased risk of DM complications and functional morbidity. The independent effect of depression on mortality in patients with DM is unclear, and relevant Asian studies have provided inconsistent results. Accordingly, this study assessed the independent and additive effects of DM and depression on mortality in a nationally representative cohort of older adults in Taiwan over a 10-year observation period. PATIENTS AND METHODS: A total of 5041 participants aged 50 years or older were observed between 1996 and 2007. We defined depression as a score of ≥8 on the 10-item Center for Epidemiologic Studies Depression (CES-D 10) scale. Additionally, we defined participants as having type 2 DM if they had received a diagnosis of type 2 DM from a health-care provider. Cox proportional hazard models were applied to analyze predictors of mortality in depression and DM comorbidity groups. RESULTS: During the 10-year follow-up period, 1637 deaths were documented. After adjustment for potential confounders, the hazard ratios for mortality in participants with both depression and DM, DM only, and depression only were 2.47 (95% confidence interval [CI]: 2.02–3.03), 1.95 (95% CI: 1.63–2.32), and 1.23 (95% CI: 1.09–1.39), respectively. CONCLUSION: The co-occurrence of depression with DM in Asian adults increased overall mortality rates. Our results indicate that the increased mortality hazard in individuals with DM and depression was independent of sex. Dove 2022-11-10 /pmc/articles/PMC9662019/ /pubmed/36387945 http://dx.doi.org/10.2147/NDT.S379174 Text en © 2022 Chen et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Chen, Vincent Chin-Hung
Wang, Tsu-Nai
Hsieh, Ming-Chia
Chou, Shih-Yong
Lee, Meng-Chih
McIntyre, Roger S
Lu, Mong-Liang
Liao, Yin-To
Yeh, Chih-Jung
Depression, Diabetes Mellitus and Mortality in Older Adults: A National Cohort Study in Taiwan
title Depression, Diabetes Mellitus and Mortality in Older Adults: A National Cohort Study in Taiwan
title_full Depression, Diabetes Mellitus and Mortality in Older Adults: A National Cohort Study in Taiwan
title_fullStr Depression, Diabetes Mellitus and Mortality in Older Adults: A National Cohort Study in Taiwan
title_full_unstemmed Depression, Diabetes Mellitus and Mortality in Older Adults: A National Cohort Study in Taiwan
title_short Depression, Diabetes Mellitus and Mortality in Older Adults: A National Cohort Study in Taiwan
title_sort depression, diabetes mellitus and mortality in older adults: a national cohort study in taiwan
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9662019/
https://www.ncbi.nlm.nih.gov/pubmed/36387945
http://dx.doi.org/10.2147/NDT.S379174
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