A novel RBD-protein/peptide vaccine elicits broadly neutralizing antibodies and protects mice and macaques against SARS-CoV-2

The development of safe and effective vaccines to respond to COVID-19 pandemic/endemic remains a priority. We developed a novel subunit protein-peptide COVID-19 vaccine candidate (UB-612) composed of: (i) receptor binding domain of SARS-CoV-2 spike protein fused to a modified single-chain human IgG1...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Shixia, Wang, Chang Yi, Kuo, Hui-Kai, Peng, Wen-Jiun, Huang, Juin-Hua, Kuo, Be-Shen, Lin, Feng, Liu, Yaw-Jen, Liu, Zhi, Wu, Huang-Ting, Ding, Shuang, Hou, Kou-Liang, Cheng, Jennifer, Yang, Ya-Ting, Jiang, Ming-Han, Wang, Min-Sheng, Chen, Tony, Xia, Wei Guo, Lin, Ed, Hung, Chung Ho, Chen, Hui-Jung, Shih, Zhonghao, Lin, Yi Ling, Ryan, Valorie, Hu, Mei Mei, Heppner, D. Gray, Malherbe, Delphine C., Periasamy, Sivakumar, Kuzmina, Natalia, Subramani, Chandru, Hellerstein, Michael, Monath, Thomas P., Rumyantsev, Alexander, Bukreyev, Alexander, Guirakhoo, Farshad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Coronaviruses
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9662039/
https://www.ncbi.nlm.nih.gov/pubmed/36287714
http://dx.doi.org/10.1080/22221751.2022.2140608

Ejemplares similares

Ejemplares similares