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A Case of Acquired Hemophilia A and Congenital Hemophilia B

Congenital hemophilia B is a rare, inherited X-linked bleeding disorder caused by a deficiency of factor IX (FIX). Acquired hemophilia A is a rare, acquired bleeding disorder which presents as new onset bleeding in older adults due to the development of autoantibodies against factor VIII (FVIII). Th...

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Autores principales: Fortier, Julia C, Pang, Shiyi S, Amofa-Ho, Sam, Harris, Neil S, Zumberg, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9662256/
https://www.ncbi.nlm.nih.gov/pubmed/36407152
http://dx.doi.org/10.7759/cureus.30324
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author Fortier, Julia C
Pang, Shiyi S
Amofa-Ho, Sam
Harris, Neil S
Zumberg, Marc
author_facet Fortier, Julia C
Pang, Shiyi S
Amofa-Ho, Sam
Harris, Neil S
Zumberg, Marc
author_sort Fortier, Julia C
collection PubMed
description Congenital hemophilia B is a rare, inherited X-linked bleeding disorder caused by a deficiency of factor IX (FIX). Acquired hemophilia A is a rare, acquired bleeding disorder which presents as new onset bleeding in older adults due to the development of autoantibodies against factor VIII (FVIII). This report describes the management of a patient with congenital hemophilia B and acquired hemophilia A. We highlight the limitations in maintaining FVIII levels using factor replacement alone and the need for escalating treatment such as rituximab and prednisone in patients with acquired hemophilia A. This case demonstrates the importance of continuing to pursue alternative diagnoses when existing ones do not explain the full clinical picture and laboratory data is inconclusive.
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spelling pubmed-96622562022-11-17 A Case of Acquired Hemophilia A and Congenital Hemophilia B Fortier, Julia C Pang, Shiyi S Amofa-Ho, Sam Harris, Neil S Zumberg, Marc Cureus Hematology Congenital hemophilia B is a rare, inherited X-linked bleeding disorder caused by a deficiency of factor IX (FIX). Acquired hemophilia A is a rare, acquired bleeding disorder which presents as new onset bleeding in older adults due to the development of autoantibodies against factor VIII (FVIII). This report describes the management of a patient with congenital hemophilia B and acquired hemophilia A. We highlight the limitations in maintaining FVIII levels using factor replacement alone and the need for escalating treatment such as rituximab and prednisone in patients with acquired hemophilia A. This case demonstrates the importance of continuing to pursue alternative diagnoses when existing ones do not explain the full clinical picture and laboratory data is inconclusive. Cureus 2022-10-15 /pmc/articles/PMC9662256/ /pubmed/36407152 http://dx.doi.org/10.7759/cureus.30324 Text en Copyright © 2022, Fortier et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Hematology
Fortier, Julia C
Pang, Shiyi S
Amofa-Ho, Sam
Harris, Neil S
Zumberg, Marc
A Case of Acquired Hemophilia A and Congenital Hemophilia B
title A Case of Acquired Hemophilia A and Congenital Hemophilia B
title_full A Case of Acquired Hemophilia A and Congenital Hemophilia B
title_fullStr A Case of Acquired Hemophilia A and Congenital Hemophilia B
title_full_unstemmed A Case of Acquired Hemophilia A and Congenital Hemophilia B
title_short A Case of Acquired Hemophilia A and Congenital Hemophilia B
title_sort case of acquired hemophilia a and congenital hemophilia b
topic Hematology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9662256/
https://www.ncbi.nlm.nih.gov/pubmed/36407152
http://dx.doi.org/10.7759/cureus.30324
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