Exosomes as a Cell-free Therapy for Myocardial Injury Following Acute Myocardial Infarction or Ischemic Reperfusion

Exosomes, which contain miRNA, have been receiving growing attention in cardiovascular therapy because of their role in mediating cell-cell communication, autophagy, apoptosis, inflammation, and angiogenesis. Several studies have suggested that miRNA derived from exosomes can be used to detect myoca...

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Autores principales: An, Ziyu, Tian, Jinfan, Liu, Yue, Zhao, Xin, Yang, Xueyao, Yong, Jingwen, Liu, Libo, Zhang, Lijun, Jiang, Wenjian, Song, Xiantao, Zhang, Hongjia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JKL International LLC 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9662265/
https://www.ncbi.nlm.nih.gov/pubmed/36465167
http://dx.doi.org/10.14336/AD.2022.0416
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author An, Ziyu
Tian, Jinfan
Liu, Yue
Zhao, Xin
Yang, Xueyao
Yong, Jingwen
Liu, Libo
Zhang, Lijun
Jiang, Wenjian
Song, Xiantao
Zhang, Hongjia
author_facet An, Ziyu
Tian, Jinfan
Liu, Yue
Zhao, Xin
Yang, Xueyao
Yong, Jingwen
Liu, Libo
Zhang, Lijun
Jiang, Wenjian
Song, Xiantao
Zhang, Hongjia
author_sort An, Ziyu
collection PubMed
description Exosomes, which contain miRNA, have been receiving growing attention in cardiovascular therapy because of their role in mediating cell-cell communication, autophagy, apoptosis, inflammation, and angiogenesis. Several studies have suggested that miRNA derived from exosomes can be used to detect myocardial infarctions (MI) in patients. Basic research also suggests that exosomes could serve as a potential therapeutic target for treating acute myocardial infarction. Ischemia/reperfusion (IR) injury is associated with adverse cardiac events after acute MI. We aim to review the potential benefits and mechanisms of exosomes in treating MI and IR injury.
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spelling pubmed-96622652022-12-01 Exosomes as a Cell-free Therapy for Myocardial Injury Following Acute Myocardial Infarction or Ischemic Reperfusion An, Ziyu Tian, Jinfan Liu, Yue Zhao, Xin Yang, Xueyao Yong, Jingwen Liu, Libo Zhang, Lijun Jiang, Wenjian Song, Xiantao Zhang, Hongjia Aging Dis Review Exosomes, which contain miRNA, have been receiving growing attention in cardiovascular therapy because of their role in mediating cell-cell communication, autophagy, apoptosis, inflammation, and angiogenesis. Several studies have suggested that miRNA derived from exosomes can be used to detect myocardial infarctions (MI) in patients. Basic research also suggests that exosomes could serve as a potential therapeutic target for treating acute myocardial infarction. Ischemia/reperfusion (IR) injury is associated with adverse cardiac events after acute MI. We aim to review the potential benefits and mechanisms of exosomes in treating MI and IR injury. JKL International LLC 2022-12-01 /pmc/articles/PMC9662265/ /pubmed/36465167 http://dx.doi.org/10.14336/AD.2022.0416 Text en copyright: © 2022 An et al. https://creativecommons.org/licenses/by/2.0/this is an open access article distributed under the terms of the creative commons attribution license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Review
An, Ziyu
Tian, Jinfan
Liu, Yue
Zhao, Xin
Yang, Xueyao
Yong, Jingwen
Liu, Libo
Zhang, Lijun
Jiang, Wenjian
Song, Xiantao
Zhang, Hongjia
Exosomes as a Cell-free Therapy for Myocardial Injury Following Acute Myocardial Infarction or Ischemic Reperfusion
title Exosomes as a Cell-free Therapy for Myocardial Injury Following Acute Myocardial Infarction or Ischemic Reperfusion
title_full Exosomes as a Cell-free Therapy for Myocardial Injury Following Acute Myocardial Infarction or Ischemic Reperfusion
title_fullStr Exosomes as a Cell-free Therapy for Myocardial Injury Following Acute Myocardial Infarction or Ischemic Reperfusion
title_full_unstemmed Exosomes as a Cell-free Therapy for Myocardial Injury Following Acute Myocardial Infarction or Ischemic Reperfusion
title_short Exosomes as a Cell-free Therapy for Myocardial Injury Following Acute Myocardial Infarction or Ischemic Reperfusion
title_sort exosomes as a cell-free therapy for myocardial injury following acute myocardial infarction or ischemic reperfusion
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9662265/
https://www.ncbi.nlm.nih.gov/pubmed/36465167
http://dx.doi.org/10.14336/AD.2022.0416
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