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Melatonin as an Antioxidant Agent in Stroke: An Updated Review

Stroke is a devastating disease associated with high mortality and disability worldwide, and is generally classified as ischemic or hemorrhagic, which share certain similar pathophysiological processes. Oxidative stress is a critical factor involved in stroke-induced injury, which not only directly...

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Autores principales: Wang, Junjie, Gao, Shiqi, Lenahan, Cameron, Gu, Yichen, Wang, Xiaoyu, Fang, Yuanjian, Xu, Weilin, Wu, Haijian, Pan, Yuanbo, Shao, Anwen, Zhang, Jianmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JKL International LLC 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9662272/
https://www.ncbi.nlm.nih.gov/pubmed/36465183
http://dx.doi.org/10.14336/AD.2022.0405
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author Wang, Junjie
Gao, Shiqi
Lenahan, Cameron
Gu, Yichen
Wang, Xiaoyu
Fang, Yuanjian
Xu, Weilin
Wu, Haijian
Pan, Yuanbo
Shao, Anwen
Zhang, Jianmin
author_facet Wang, Junjie
Gao, Shiqi
Lenahan, Cameron
Gu, Yichen
Wang, Xiaoyu
Fang, Yuanjian
Xu, Weilin
Wu, Haijian
Pan, Yuanbo
Shao, Anwen
Zhang, Jianmin
author_sort Wang, Junjie
collection PubMed
description Stroke is a devastating disease associated with high mortality and disability worldwide, and is generally classified as ischemic or hemorrhagic, which share certain similar pathophysiological processes. Oxidative stress is a critical factor involved in stroke-induced injury, which not only directly damages brain tissue, but also enhances a series of pathological signaling cascades, contributing to inflammation, brain edema, and neuronal death. To alleviate these serious secondary brain injuries, neuroprotective agents targeting oxidative stress inhibition may serve as a promising treatment strategy. Melatonin is a hormone secreted by the pineal gland, and has various properties, such as antioxidation, anti-inflammation, circadian rhythm modulation, and promotion of tissue regeneration. Numerous animal experiments studying stroke have confirmed that melatonin exerts considerable neuroprotective effects, partially via anti-oxidative stress. In this review, we introduce the possible role of melatonin as an antioxidant in the treatment of stroke based on the latest published studies of animal experiments and clinical research.
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spelling pubmed-96622722022-12-01 Melatonin as an Antioxidant Agent in Stroke: An Updated Review Wang, Junjie Gao, Shiqi Lenahan, Cameron Gu, Yichen Wang, Xiaoyu Fang, Yuanjian Xu, Weilin Wu, Haijian Pan, Yuanbo Shao, Anwen Zhang, Jianmin Aging Dis Review Stroke is a devastating disease associated with high mortality and disability worldwide, and is generally classified as ischemic or hemorrhagic, which share certain similar pathophysiological processes. Oxidative stress is a critical factor involved in stroke-induced injury, which not only directly damages brain tissue, but also enhances a series of pathological signaling cascades, contributing to inflammation, brain edema, and neuronal death. To alleviate these serious secondary brain injuries, neuroprotective agents targeting oxidative stress inhibition may serve as a promising treatment strategy. Melatonin is a hormone secreted by the pineal gland, and has various properties, such as antioxidation, anti-inflammation, circadian rhythm modulation, and promotion of tissue regeneration. Numerous animal experiments studying stroke have confirmed that melatonin exerts considerable neuroprotective effects, partially via anti-oxidative stress. In this review, we introduce the possible role of melatonin as an antioxidant in the treatment of stroke based on the latest published studies of animal experiments and clinical research. JKL International LLC 2022-12-01 /pmc/articles/PMC9662272/ /pubmed/36465183 http://dx.doi.org/10.14336/AD.2022.0405 Text en copyright: © 2022 Wang et al. https://creativecommons.org/licenses/by/2.0/this is an open access article distributed under the terms of the creative commons attribution license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Review
Wang, Junjie
Gao, Shiqi
Lenahan, Cameron
Gu, Yichen
Wang, Xiaoyu
Fang, Yuanjian
Xu, Weilin
Wu, Haijian
Pan, Yuanbo
Shao, Anwen
Zhang, Jianmin
Melatonin as an Antioxidant Agent in Stroke: An Updated Review
title Melatonin as an Antioxidant Agent in Stroke: An Updated Review
title_full Melatonin as an Antioxidant Agent in Stroke: An Updated Review
title_fullStr Melatonin as an Antioxidant Agent in Stroke: An Updated Review
title_full_unstemmed Melatonin as an Antioxidant Agent in Stroke: An Updated Review
title_short Melatonin as an Antioxidant Agent in Stroke: An Updated Review
title_sort melatonin as an antioxidant agent in stroke: an updated review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9662272/
https://www.ncbi.nlm.nih.gov/pubmed/36465183
http://dx.doi.org/10.14336/AD.2022.0405
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