Neuron-targeted Knockout of APE1 Forces Premature Cognitive Impairment and Synaptic Dysfunction in Adult Mice

Adaptable and consistent neural function relies at least in part on the ongoing repair of oxidative damage that can accumulate in the brain over a lifespan. To determine whether forebrain neuron-targeted knockout of AP endonuclease 1 (APE1), a critical enzyme in the base excision DNA repair pathway,...

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Detalles Bibliográficos
Autores principales: Zhu, Ling, Hassan, Sulaiman H., Gao, Xuguang, Johnson, Joycelyn Q., Wang, Yangfan, Bregy, M. Victoria, Wei, Zhishuo, Chen, Jun, Li, Peiying, Stetler, R. Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JKL International LLC 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9662274/
https://www.ncbi.nlm.nih.gov/pubmed/36465182
http://dx.doi.org/10.14336/AD.2022.0331

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