Cargando…

Epidemiological Characteristics and Role of Connexin-43 in Patients of Syndactyly Attending a Tertiary Care Center in Odisha, India

Background: Syndactyly is one of the most common hereditary limb malformations. Yet, epidemiological data in our state is not reported. The current study aims to understand the Connexin-43 expression in such patients. Methodology: A retrospective cohort study was done in the Department of Plastic su...

Descripción completa

Detalles Bibliográficos
Autores principales: Sahoo, Sanjukta, Banik, Suranjana, Giri, Sanjay K, Tripathy, Prabhas R, Kumar, KC Pradheep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9662593/
https://www.ncbi.nlm.nih.gov/pubmed/36407278
http://dx.doi.org/10.7759/cureus.30327
_version_ 1784830718207066112
author Sahoo, Sanjukta
Banik, Suranjana
Giri, Sanjay K
Tripathy, Prabhas R
Kumar, KC Pradheep
author_facet Sahoo, Sanjukta
Banik, Suranjana
Giri, Sanjay K
Tripathy, Prabhas R
Kumar, KC Pradheep
author_sort Sahoo, Sanjukta
collection PubMed
description Background: Syndactyly is one of the most common hereditary limb malformations. Yet, epidemiological data in our state is not reported. The current study aims to understand the Connexin-43 expression in such patients. Methodology: A retrospective cohort study was done in the Department of Plastic surgery and Anatomy of All India Institute of Medical Sciences (AIIMS), Bhubaneswar. The study duration was three years, between 2019 and 2022. The total number of cases was 49 and included patients diagnosed with Syndactyly seeking surgical intervention. The demographic details and the personal and disease history were collected, analyzed, and interpreted. Immunohistochemistry study using Connexin-43. Results: Out of the 49 patients, 26 (53.1%) were male, and 23 (46.9%) were female. Thirty nine (79.6%) had syndactyly, and 10 (20.4%) were diagnosed with syndactyly associated with another syndrome. Both complete and incomplete syndactyly was found. Strong membranous positivity of Connexin-43 was found in the keratinocytes of the stratum spinosum layer of the epidermis, while the stratum granulosum and stratum basale layer revealed negative staining. Conclusions: Syndactyly is mostly non-familial, sporadic with male preponderance affecting unilaterally and in incomplete form in our geographical location. We found an overt expression of Connexin-43 in these patients' stratum basale.
format Online
Article
Text
id pubmed-9662593
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Cureus
record_format MEDLINE/PubMed
spelling pubmed-96625932022-11-17 Epidemiological Characteristics and Role of Connexin-43 in Patients of Syndactyly Attending a Tertiary Care Center in Odisha, India Sahoo, Sanjukta Banik, Suranjana Giri, Sanjay K Tripathy, Prabhas R Kumar, KC Pradheep Cureus Plastic Surgery Background: Syndactyly is one of the most common hereditary limb malformations. Yet, epidemiological data in our state is not reported. The current study aims to understand the Connexin-43 expression in such patients. Methodology: A retrospective cohort study was done in the Department of Plastic surgery and Anatomy of All India Institute of Medical Sciences (AIIMS), Bhubaneswar. The study duration was three years, between 2019 and 2022. The total number of cases was 49 and included patients diagnosed with Syndactyly seeking surgical intervention. The demographic details and the personal and disease history were collected, analyzed, and interpreted. Immunohistochemistry study using Connexin-43. Results: Out of the 49 patients, 26 (53.1%) were male, and 23 (46.9%) were female. Thirty nine (79.6%) had syndactyly, and 10 (20.4%) were diagnosed with syndactyly associated with another syndrome. Both complete and incomplete syndactyly was found. Strong membranous positivity of Connexin-43 was found in the keratinocytes of the stratum spinosum layer of the epidermis, while the stratum granulosum and stratum basale layer revealed negative staining. Conclusions: Syndactyly is mostly non-familial, sporadic with male preponderance affecting unilaterally and in incomplete form in our geographical location. We found an overt expression of Connexin-43 in these patients' stratum basale. Cureus 2022-10-15 /pmc/articles/PMC9662593/ /pubmed/36407278 http://dx.doi.org/10.7759/cureus.30327 Text en Copyright © 2022, Sahoo et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Plastic Surgery
Sahoo, Sanjukta
Banik, Suranjana
Giri, Sanjay K
Tripathy, Prabhas R
Kumar, KC Pradheep
Epidemiological Characteristics and Role of Connexin-43 in Patients of Syndactyly Attending a Tertiary Care Center in Odisha, India
title Epidemiological Characteristics and Role of Connexin-43 in Patients of Syndactyly Attending a Tertiary Care Center in Odisha, India
title_full Epidemiological Characteristics and Role of Connexin-43 in Patients of Syndactyly Attending a Tertiary Care Center in Odisha, India
title_fullStr Epidemiological Characteristics and Role of Connexin-43 in Patients of Syndactyly Attending a Tertiary Care Center in Odisha, India
title_full_unstemmed Epidemiological Characteristics and Role of Connexin-43 in Patients of Syndactyly Attending a Tertiary Care Center in Odisha, India
title_short Epidemiological Characteristics and Role of Connexin-43 in Patients of Syndactyly Attending a Tertiary Care Center in Odisha, India
title_sort epidemiological characteristics and role of connexin-43 in patients of syndactyly attending a tertiary care center in odisha, india
topic Plastic Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9662593/
https://www.ncbi.nlm.nih.gov/pubmed/36407278
http://dx.doi.org/10.7759/cureus.30327
work_keys_str_mv AT sahoosanjukta epidemiologicalcharacteristicsandroleofconnexin43inpatientsofsyndactylyattendingatertiarycarecenterinodishaindia
AT baniksuranjana epidemiologicalcharacteristicsandroleofconnexin43inpatientsofsyndactylyattendingatertiarycarecenterinodishaindia
AT girisanjayk epidemiologicalcharacteristicsandroleofconnexin43inpatientsofsyndactylyattendingatertiarycarecenterinodishaindia
AT tripathyprabhasr epidemiologicalcharacteristicsandroleofconnexin43inpatientsofsyndactylyattendingatertiarycarecenterinodishaindia
AT kumarkcpradheep epidemiologicalcharacteristicsandroleofconnexin43inpatientsofsyndactylyattendingatertiarycarecenterinodishaindia