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Cardiorespiratory Optimal Point Is a Submaximal Exercise Test Variable and a Predictor of Mortality Risk: THE BALL STATE ADULT FITNESS LONGITUDINAL LIFESTYLE STUDY (BALL ST)

The cardiorespiratory optimal point (COP) is the minimum ventilatory equivalent for oxygen. The COP can be determined during a submaximal incremental exercise test. Reflecting the optimal interaction between the respiratory and cardiovascular systems, COP may have prognostic utility. The aim of this...

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Autores principales: Peterman, James E., Harber, Matthew P., Fleenor, Bradley S., Whaley, Mitchell H., Araújo, Claudio G., Kaminsky, Leonard A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health, Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9662820/
https://www.ncbi.nlm.nih.gov/pubmed/35861956
http://dx.doi.org/10.1097/HCR.0000000000000711
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author Peterman, James E.
Harber, Matthew P.
Fleenor, Bradley S.
Whaley, Mitchell H.
Araújo, Claudio G.
Kaminsky, Leonard A.
author_facet Peterman, James E.
Harber, Matthew P.
Fleenor, Bradley S.
Whaley, Mitchell H.
Araújo, Claudio G.
Kaminsky, Leonard A.
author_sort Peterman, James E.
collection PubMed
description The cardiorespiratory optimal point (COP) is the minimum ventilatory equivalent for oxygen. The COP can be determined during a submaximal incremental exercise test. Reflecting the optimal interaction between the respiratory and cardiovascular systems, COP may have prognostic utility. The aim of this investigation was to determine the relationship between COP and all-cause mortality in a cohort of apparently healthy adults. METHODS: The sample included 3160 apparently healthy adults (46% females) with a mean age of 44.0 ± 12.5 yr who performed a cardiopulmonary exercise test. Cox proportional hazards models were performed to assess the relationship between COP and mortality risk. Prognostic peak oxygen uptake (V˙o(2peak)) and COP models were compared using the concordance index. RESULTS: There were 558 deaths (31% females) over a follow-up period of 23.0 ± 11.9 yr. For males, all Cox proportional hazards models, including the model adjusted for traditional risk factors and V˙o(2peak), had a positive association with risk for mortality (P < .05). For females, only the unadjusted COP model was associated with risk for mortality (P < .05). The concordance index values indicated that unadjusted COP models had lower discrimination compared with unadjusted V˙o(2peak) models (P < .05) and V˙o(2peak) did not complement COP models (P ≥ .13). CONCLUSIONS: Cardiorespiratory optimal point is related to all-cause mortality in males but not females. These findings suggest that a determination of COP can have prognostic utility in apparently healthy males aged 18-85 yr, which may be relevant when a maximal exercise test is not feasible or desirable.
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spelling pubmed-96628202022-11-21 Cardiorespiratory Optimal Point Is a Submaximal Exercise Test Variable and a Predictor of Mortality Risk: THE BALL STATE ADULT FITNESS LONGITUDINAL LIFESTYLE STUDY (BALL ST) Peterman, James E. Harber, Matthew P. Fleenor, Bradley S. Whaley, Mitchell H. Araújo, Claudio G. Kaminsky, Leonard A. J Cardiopulm Rehabil Prev Prevention The cardiorespiratory optimal point (COP) is the minimum ventilatory equivalent for oxygen. The COP can be determined during a submaximal incremental exercise test. Reflecting the optimal interaction between the respiratory and cardiovascular systems, COP may have prognostic utility. The aim of this investigation was to determine the relationship between COP and all-cause mortality in a cohort of apparently healthy adults. METHODS: The sample included 3160 apparently healthy adults (46% females) with a mean age of 44.0 ± 12.5 yr who performed a cardiopulmonary exercise test. Cox proportional hazards models were performed to assess the relationship between COP and mortality risk. Prognostic peak oxygen uptake (V˙o(2peak)) and COP models were compared using the concordance index. RESULTS: There were 558 deaths (31% females) over a follow-up period of 23.0 ± 11.9 yr. For males, all Cox proportional hazards models, including the model adjusted for traditional risk factors and V˙o(2peak), had a positive association with risk for mortality (P < .05). For females, only the unadjusted COP model was associated with risk for mortality (P < .05). The concordance index values indicated that unadjusted COP models had lower discrimination compared with unadjusted V˙o(2peak) models (P < .05) and V˙o(2peak) did not complement COP models (P ≥ .13). CONCLUSIONS: Cardiorespiratory optimal point is related to all-cause mortality in males but not females. These findings suggest that a determination of COP can have prognostic utility in apparently healthy males aged 18-85 yr, which may be relevant when a maximal exercise test is not feasible or desirable. Wolters Kluwer Health, Inc. 2022-11 2022-07-07 /pmc/articles/PMC9662820/ /pubmed/35861956 http://dx.doi.org/10.1097/HCR.0000000000000711 Text en © 2022 The Authors. Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Prevention
Peterman, James E.
Harber, Matthew P.
Fleenor, Bradley S.
Whaley, Mitchell H.
Araújo, Claudio G.
Kaminsky, Leonard A.
Cardiorespiratory Optimal Point Is a Submaximal Exercise Test Variable and a Predictor of Mortality Risk: THE BALL STATE ADULT FITNESS LONGITUDINAL LIFESTYLE STUDY (BALL ST)
title Cardiorespiratory Optimal Point Is a Submaximal Exercise Test Variable and a Predictor of Mortality Risk: THE BALL STATE ADULT FITNESS LONGITUDINAL LIFESTYLE STUDY (BALL ST)
title_full Cardiorespiratory Optimal Point Is a Submaximal Exercise Test Variable and a Predictor of Mortality Risk: THE BALL STATE ADULT FITNESS LONGITUDINAL LIFESTYLE STUDY (BALL ST)
title_fullStr Cardiorespiratory Optimal Point Is a Submaximal Exercise Test Variable and a Predictor of Mortality Risk: THE BALL STATE ADULT FITNESS LONGITUDINAL LIFESTYLE STUDY (BALL ST)
title_full_unstemmed Cardiorespiratory Optimal Point Is a Submaximal Exercise Test Variable and a Predictor of Mortality Risk: THE BALL STATE ADULT FITNESS LONGITUDINAL LIFESTYLE STUDY (BALL ST)
title_short Cardiorespiratory Optimal Point Is a Submaximal Exercise Test Variable and a Predictor of Mortality Risk: THE BALL STATE ADULT FITNESS LONGITUDINAL LIFESTYLE STUDY (BALL ST)
title_sort cardiorespiratory optimal point is a submaximal exercise test variable and a predictor of mortality risk: the ball state adult fitness longitudinal lifestyle study (ball st)
topic Prevention
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9662820/
https://www.ncbi.nlm.nih.gov/pubmed/35861956
http://dx.doi.org/10.1097/HCR.0000000000000711
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