TCR-Independent Metabolic Reprogramming Precedes Lymphoma-Driven Changes in T-cell Fate

Chronic T-cell receptor (TCR) signaling in the tumor microenvironment is known to promote T-cell dysfunction. However, we reasoned that poorly immunogenic tumors may also compromise T cells by impairing their metabolism. To address this, we assessed temporal changes in T-cell metabolism, fate, and f...

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Detalles Bibliográficos
Autores principales: Hesterberg, Rebecca S., Liu, Min, Elmarsafawi, Aya G., Koomen, John M., Welsh, Eric A., Hesterberg, Stephen G., Ranatunga, Sujeewa, Yang, Chunying, Li, Weimin, Lawrence, Harshani R., Rodriguez, Paulo C., Berglund, Anders E., Cleveland, John L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9662872/
https://www.ncbi.nlm.nih.gov/pubmed/35969234
http://dx.doi.org/10.1158/2326-6066.CIR-21-0813

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