Loss of function of the nuclear envelope protein LEMD2 causes DNA damage–dependent cardiomyopathy

Mutations in nuclear envelope proteins (NEPs) cause devastating genetic diseases, known as envelopathies, that primarily affect the heart and skeletal muscle. A mutation in the NEP LEM domain–containing protein 2 (LEMD2) causes severe cardiomyopathy in humans. However, the roles of LEMD2 in the hear...

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Detalles Bibliográficos
Autores principales: Caravia, Xurde M., Ramirez-Martinez, Andres, Gan, Peiheng, Wang, Feng, McAnally, John R., Xu, Lin, Bassel-Duby, Rhonda, Liu, Ning, Olson, Eric N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9663152/
https://www.ncbi.nlm.nih.gov/pubmed/36377660
http://dx.doi.org/10.1172/JCI158897

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