CBFA2T3-GLIS2 model of pediatric acute megakaryoblastic leukemia identifies FOLR1 as a CAR T cell target

The CBFA2T3-GLIS2 (C/G) fusion is a product of a cryptic translocation primarily seen in infants and early childhood and is associated with dismal outcome. Here, we demonstrate that the expression of the C/G oncogenic fusion protein promotes the transformation of human cord blood hematopoietic stem...

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Detalles Bibliográficos
Autores principales: Le, Quy, Hadland, Brandon, Smith, Jenny L., Leonti, Amanda, Huang, Benjamin J., Ries, Rhonda, Hylkema, Tiffany A., Castro, Sommer, Tang, Thao T., McKay, Cyd N., Perkins, LaKeisha, Pardo, Laura, Sarthy, Jay, Beckman, Amy K., Williams, Robin, Idemmili, Rhonda, Furlan, Scott, Ishida, Takashi, Call, Lindsey, Srivastava, Shivani, Loeb, Anisha M., Milano, Filippo, Imren, Suzan, Morris, Shelli M., Pakiam, Fiona, Olson, Jim M., Loken, Michael R., Brodersen, Lisa, Riddell, Stanley R., Tarlock, Katherine, Bernstein, Irwin D., Loeb, Keith R., Meshinchi, Soheil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9663156/
https://www.ncbi.nlm.nih.gov/pubmed/36136600
http://dx.doi.org/10.1172/JCI157101

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