Istradefylline protects from cisplatin-induced nephrotoxicity and peripheral neuropathy while preserving cisplatin antitumor effects

Cisplatin is a potent chemotherapeutic drug that is widely used in the treatment of various solid cancers. However, its clinical effectiveness is strongly limited by frequent severe adverse effects, in particular nephrotoxicity and chemotherapy-induced peripheral neuropathy. Thus, there is an urgent...

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Detalles Bibliográficos
Autores principales: Dewaeles, Edmone, Carvalho, Kévin, Fellah, Sandy, Sim, Jaewon, Boukrout, Nihad, Caillierez, Raphaelle, Ramakrishnan, Hariharan, Van der Hauwaert, Cynthia, Vijaya Shankara, Jhenkruthi, Martin, Nathalie, Massri, Noura, Launay, Agathe, Folger, Joseph K., de Schutter, Clémentine, Larrue, Romain, Loison, Ingrid, Goujon, Marine, Jung, Matthieu, Le Gras, Stéphanie, Gomez-Murcia, Victoria, Faivre, Emilie, Lemaire, Julie, Garat, Anne, Beauval, Nicolas, Maboudou, Patrice, Gnemmi, Viviane, Gibier, Jean-Baptiste, Buée, Luc, Abbadie, Corinne, Glowacki, Francois, Pottier, Nicolas, Perrais, Michael, Cunha, Rodrigo A., Annicotte, Jean-Sébastien, Laumet, Geoffroy, Blum, David, Cauffiez, Christelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9663157/
https://www.ncbi.nlm.nih.gov/pubmed/36377661
http://dx.doi.org/10.1172/JCI152924

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