Mesenchymal cell replacement corrects thymic hypoplasia in murine models of 22q11.2 deletion syndrome

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22q11.2 deletion syndrome (22q11.2DS) is the most common human chromosomal microdeletion, causing developmentally linked congenital malformations, thymic hypoplasia, hypoparathyroidism, and/or cardiac defects. Thymic hypoplasia leads to T cell lymphopenia, which most often results in mild SCID. Desp...

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Detalles Bibliográficos
Autores principales: Bhalla, Pratibha, Du, Qiumei, Kumar, Ashwani, Xing, Chao, Moses, Angela, Dozmorov, Igor, Wysocki, Christian A., Cleaver, Ondine B., Pirolli, Timothy J., Markert, Mary Louise, de la Morena, Maria Teresa, Baldini, Antonio, van Oers, Nicolai S.C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9663160/
https://www.ncbi.nlm.nih.gov/pubmed/36136514
http://dx.doi.org/10.1172/JCI160101
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