H3.3-G34 mutations impair DNA repair and promote cGAS/STING-mediated immune responses in pediatric high-grade glioma models

Pediatric high-grade gliomas (pHGGs) are the leading cause of cancer-related deaths in children in the USA. Sixteen percent of hemispheric pediatric and young adult HGGs encode Gly34Arg/Val substitutions in the histone H3.3 (H3.3-G34R/V). The mechanisms by which H3.3-G34R/V drive malignancy and ther...

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Detalles Bibliográficos
Autores principales: Haase, Santiago, Banerjee, Kaushik, Mujeeb, Anzar A., Hartlage, Carson S., Núñez, Fernando M., Núñez, Felipe J., Alghamri, Mahmoud S., Kadiyala, Padma, Carney, Stephen, Barissi, Marcus N., Taher, Ayman W., Brumley, Emily K., Thompson, Sarah, Dreyer, Justin T., Alindogan, Caitlin T., Garcia-Fabiani, Maria B., Comba, Andrea, Venneti, Sriram, Ravikumar, Visweswaran, Koschmann, Carl, Carcaboso, Ángel M., Vinci, Maria, Rao, Arvind, Yu, Jennifer S., Lowenstein, Pedro R., Castro, Maria G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9663161/
https://www.ncbi.nlm.nih.gov/pubmed/36125896
http://dx.doi.org/10.1172/JCI154229

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