IL-17D-induced inhibition of DDX5 expression in keratinocytes amplifies IL-36R-mediated skin inflammation

Aberrant RNA splicing in keratinocytes drives inflammatory skin disorders. In the present study, we found that the RNA helicase DDX5 was downregulated in keratinocytes from the inflammatory skin lesions in patients with atopic dermatitis and psoriasis, and that mice with keratinocyte-specific deleti...

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Detalles Bibliográficos
Autores principales: Ni, Xinhui, Xu, Yi, Wang, Wang, Kong, Baida, Ouyang, Jian, Chen, Jiwei, Yan, Man, Wu, Yawei, Chen, Qi, Wang, Xinxin, Li, Hongquan, Gao, Xiaoguang, Guo, Hongquan, Cui, Lian, Chen, Zeyu, Shi, Yuling, Zhu, Ronghui, Li, Wei, Shi, Tieliu, Wang, Lin-Fa, Huang, Jinling, Dong, Chen, Lai, Yuping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9663298/
https://www.ncbi.nlm.nih.gov/pubmed/36271146
http://dx.doi.org/10.1038/s41590-022-01339-3

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