Functional characterization of the PI3K/AKT/MTOR signaling pathway for targeted therapy in B-precursor acute lymphoblastic leukemia

B-cell precursor acute lymphoblastic leukemias (B-ALL) are characterized by the activation of signaling pathways, which are involved in survival and proliferation of leukemia cells. Using an unbiased shRNA library screen enriched for targeting signaling pathways, we identified MTOR as the key gene o...

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Detalles Bibliográficos
Autores principales: Grüninger, Patricia K., Uhl, Franziska, Herzog, Heike, Gentile, Gaia, Andrade-Martinez, Marta, Schmidt, Tobias, Han, Kyuho, Morgens, David W., Bassik, Michael C., Cleary, Michael L., Gorka, Oliver, Zeiser, Robert, Groß, Olaf, Duque-Afonso, Jesús
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9663301/
https://www.ncbi.nlm.nih.gov/pubmed/35794338
http://dx.doi.org/10.1038/s41417-022-00491-0

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