Cargando…

Pleiotropic genetic architecture and novel loci for C-reactive protein levels

C-reactive protein is involved in a plethora of pathophysiological conditions. Many genetic loci associated with C-reactive protein are annotated to lipid and glucose metabolism genes supporting common biological pathways between inflammation and metabolic traits. To identify novel pleiotropic loci,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Koskeridis, Fotios, Evangelou, Evangelos, Said, Saredo, Boyle, Joseph J., Elliott, Paul, Dehghan, Abbas, Tzoulaki, Ioanna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9663411/ https://www.ncbi.nlm.nih.gov/pubmed/36376304 http://dx.doi.org/10.1038/s41467-022-34688-6

Ejemplares similares

Genetic analysis of over half a million people characterises C-reactive protein loci
por: Said, Saredo, et al.
Publicado: (2022)

Author Correction: Genetic analysis of over half a million people characterises C-reactive protein loci
por: Said, Saredo, et al.
Publicado: (2022)

Associations of genetically predicted fatty acid levels across the phenome: A mendelian randomisation study
por: Zagkos, Loukas, et al.
Publicado: (2022)

Use of Genetic Variants Related to Antihypertensive Drugs to Inform on Efficacy and Side Effects
por: Gill, Dipender, et al.
Publicado: (2019)

Associations of genetically determined iron status across the phenome: A mendelian randomization study
por: Gill, Dipender, et al.
Publicado: (2019)

Genetically determined blood pressure, antihypertensive drug classes, and risk of stroke subtypes
por: Georgakis, Marios K., et al.
Publicado: (2020)

Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes
por: Pazoki, Raha, et al.
Publicado: (2021)

Bivariate genome-wide association study identifies novel pleiotropic loci for lipids and inflammation
por: Ligthart, Symen, et al.
Publicado: (2016)

PheWAS and cross-disorder analysis reveal genetic architecture, pleiotropic loci and phenotypic correlations across 11 autoimmune disorders
por: Topaloudi, Apostolia, et al.
Publicado: (2023)

GWAS for urinary sodium and potassium excretion highlights pathways shared with cardiovascular traits
por: Pazoki, Raha, et al.
Publicado: (2019)

Pathway‐based integration of multi‐omics data reveals lipidomics alterations validated in an Alzheimer's disease mouse model and risk loci carriers
por: Garcia‐Segura, Monica Emili, et al.
Publicado: (2022)

Associations of Genetically Predicted Vitamin B(12) Status across the Phenome
por: Dib, Marie-Joe, et al.
Publicado: (2022)

Genetic Effects at Pleiotropic Loci Are Context-Dependent with Consequences for the Maintenance of Genetic Variation in Populations
por: Lawson, Heather A., et al.
Publicado: (2011)

Risk factors for type 2 diabetes mellitus: An exposure-wide umbrella review of meta-analyses
por: Bellou, Vanesa, et al.
Publicado: (2018)

Pleiotropy among Common Genetic Loci Identified for Cardiometabolic Disorders and C-Reactive Protein
por: Ligthart, Symen, et al.
Publicado: (2015)

Iron Status and Risk of Stroke: A Mendelian Randomization Study
por: Gill, Dipender, et al.
Publicado: (2018)

Cooperation loci are more pleiotropic than private loci in the bacterium Pseudomonas aeruginosa
por: Scott, Trey J.
Publicado: (2022)

Accelerated MRI-predicted brain ageing and its associations with cardiometabolic and brain disorders
por: Kolbeinsson, Arinbjörn, et al.
Publicado: (2020)

Circulatory proteins relate cardiovascular disease to cognitive performance: A mendelian randomisation study
por: Huang, Jian, et al.
Publicado: (2023)

Education protects against coronary heart disease and stroke independently of cognitive function: evidence from Mendelian randomization
por: Gill, Dipender, et al.
Publicado: (2019)

Complex trait architecture: the pleiotropic model revisited
por: North, T.-L., et al.
Publicado: (2015)

Birth weight in relation to health and disease in later life: an umbrella review of systematic reviews and meta-analyses
por: Belbasis, Lazaros, et al.
Publicado: (2016)

Prognostic models for outcome prediction in patients with chronic obstructive pulmonary disease: systematic review and critical appraisal
por: Bellou, Vanesa, et al.
Publicado: (2019)

Metabolome-wide association study on physical activity
por: Kojouri, Maedeh, et al.
Publicado: (2023)

Pleiotropic Effects of Trait-Associated Genetic Variation on DNA Methylation: Utility for Refining GWAS Loci
por: Hannon, Eilis, et al.
Publicado: (2017)

An Approach to Identify New Pleiotropic Genetic Loci From Publicly Available Univariate GWAS Results
por: Loika, Yury, et al.
Publicado: (2020)

The Genetic Architecture of Ovariole Number in Drosophila melanogaster: Genes with Major, Quantitative, and Pleiotropic Effects
por: Lobell, Amanda S., et al.
Publicado: (2017)

Effects of Genetically Determined Iron Status on Risk of Venous Thromboembolism and Carotid Atherosclerotic Disease: A Mendelian Randomization Study
por: Gill, Dipender, et al.
Publicado: (2019)

Importance of vitamin D in acute and critically ill children with subgroup analyses of sepsis and respiratory tract infections: a systematic review and meta-analysis
por: Cariolou, Margarita, et al.
Publicado: (2019)

Mapping pleiotropic loci using a fast-sequential testing algorithm
por: Aguate, Fernando M., et al.
Publicado: (2021)

Awareness, knowledge and trust in the Greek authorities towards COVID-19 pandemic: results from the Epirus Health Study cohort
por: Kanellopoulou, Afroditi, et al.
Publicado: (2021)

Discovery of Novel Genetic Risk Loci for Acute Central Serous Chorioretinopathy and Genetic Pleiotropic Effect With Age-Related Macular Degeneration
por: Feng, Lei, et al.
Publicado: (2021)

Evaluation of pleiotropic effects among common genetic loci identified for cardio-metabolic traits in a Korean population
por: Kim, Yun Kyoung, et al.
Publicado: (2016)

Multi-Trait Genome-Wide Association Study of Atherosclerosis Detects Novel Pleiotropic Loci
por: Bellomo, Tiffany R., et al.
Publicado: (2022)

Detection of multiple quantitative trait loci and their pleiotropic effects in outbred pig populations
por: Nagamine, Yoshitaka, et al.
Publicado: (2009)

Cross-Cancer Pleiotropic Analysis Reveals Novel Susceptibility Loci for Lung Cancer
por: Wang, Lijuan, et al.
Publicado: (2020)

Favorable pleiotropic loci for fiber yield and quality in upland cotton (Gossypium hirsutum)
por: Wang, Pengpeng, et al.
Publicado: (2021)

Pleiotropic Loci Associated With Foot Disorders and Common Periparturient Diseases in Holstein Cattle
por: Lai, Ellen, et al.
Publicado: (2021)

Meta-analysis identifies pleiotropic loci controlling phenotypic trade-offs in sorghum
por: Mural, Ravi V, et al.
Publicado: (2021)

Complex pleiotropic genetic architecture of evolved heat stress and oxidative stress resistance in the nematode Caenorhabditis remanei
por: O’Connor, Christine H, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_5m30t3ng8rnig790rd0nlajaip