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Predictive value of S100A4 in eosinophilic chronic rhinosinusitis with nasal polyps
OBJECTIVE: S100A4 is a pro-inflammatory mediator which has been implicated in airway inflammatory diseases. However, its role in chronic rhinosinusitis with nasal polyps (CRSwNP) remains unclear. The purpose of this study is to determine the expression of S100A4 and evaluate its potential value in d...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9663474/ https://www.ncbi.nlm.nih.gov/pubmed/36386522 http://dx.doi.org/10.3389/fsurg.2022.989489 |
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author | Zou, Shangchu Huang, Zhicheng Wu, Jinpeng |
author_facet | Zou, Shangchu Huang, Zhicheng Wu, Jinpeng |
author_sort | Zou, Shangchu |
collection | PubMed |
description | OBJECTIVE: S100A4 is a pro-inflammatory mediator which has been implicated in airway inflammatory diseases. However, its role in chronic rhinosinusitis with nasal polyps (CRSwNP) remains unclear. The purpose of this study is to determine the expression of S100A4 and evaluate its potential value in distinguishing its endotypes. METHODS: Sixty CRSwNP patients, 30 chronic rhinosinusitis without nasal polyps (CRSsNP) patients, and 30 healthy controls (HC) were enrolled in this study, and serum and tissue samples were collected. Serum and tissue S100A4 levels were detected by enzyme-linked immunosorbent assay, reverse transcription-polymerase chain reaction, western blotting and immunofluorescence. Their clinical values in predicting postoperative recurrence of CRSwNP were evaluated by multivariate analysis and ROC curves. RESULTS: Serum levels of S100A4 were notably increased in the CRSwNP group than in the CRSsNP and HC groups (p < 0.05), and positively correlated with tissue and peripheral eosinophil count and percentage (p < 0.05). The serum S100A4 concentrations were significantly elevated in the Eos CRSwNP group in comparison with the non-Eos CRSwNP group (p < 0.05). Multivariate analysis and ROC curve presented that serum S100A4 levels were associated with CRSwNP endotypes. Additionally, tissue S100A4 mRNA and protein levels were significantly enhanced in the CRSwNP group than in the HC group and CRSsNP group, especially in the Eos CRSwNP group. CONCLUSION: Our results demonstrated that the S100A4 expression was increased in CRSwNP patients and associated with the endotypes. S100A4 could be a serologic biomarker for evaluating tissue eosinophilic inflammation and predicting endotypes in CRSwNP patients. |
format | Online Article Text |
id | pubmed-9663474 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96634742022-11-15 Predictive value of S100A4 in eosinophilic chronic rhinosinusitis with nasal polyps Zou, Shangchu Huang, Zhicheng Wu, Jinpeng Front Surg Surgery OBJECTIVE: S100A4 is a pro-inflammatory mediator which has been implicated in airway inflammatory diseases. However, its role in chronic rhinosinusitis with nasal polyps (CRSwNP) remains unclear. The purpose of this study is to determine the expression of S100A4 and evaluate its potential value in distinguishing its endotypes. METHODS: Sixty CRSwNP patients, 30 chronic rhinosinusitis without nasal polyps (CRSsNP) patients, and 30 healthy controls (HC) were enrolled in this study, and serum and tissue samples were collected. Serum and tissue S100A4 levels were detected by enzyme-linked immunosorbent assay, reverse transcription-polymerase chain reaction, western blotting and immunofluorescence. Their clinical values in predicting postoperative recurrence of CRSwNP were evaluated by multivariate analysis and ROC curves. RESULTS: Serum levels of S100A4 were notably increased in the CRSwNP group than in the CRSsNP and HC groups (p < 0.05), and positively correlated with tissue and peripheral eosinophil count and percentage (p < 0.05). The serum S100A4 concentrations were significantly elevated in the Eos CRSwNP group in comparison with the non-Eos CRSwNP group (p < 0.05). Multivariate analysis and ROC curve presented that serum S100A4 levels were associated with CRSwNP endotypes. Additionally, tissue S100A4 mRNA and protein levels were significantly enhanced in the CRSwNP group than in the HC group and CRSsNP group, especially in the Eos CRSwNP group. CONCLUSION: Our results demonstrated that the S100A4 expression was increased in CRSwNP patients and associated with the endotypes. S100A4 could be a serologic biomarker for evaluating tissue eosinophilic inflammation and predicting endotypes in CRSwNP patients. Frontiers Media S.A. 2022-11-01 /pmc/articles/PMC9663474/ /pubmed/36386522 http://dx.doi.org/10.3389/fsurg.2022.989489 Text en © 2022 Zou, Huang and Wu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Surgery Zou, Shangchu Huang, Zhicheng Wu, Jinpeng Predictive value of S100A4 in eosinophilic chronic rhinosinusitis with nasal polyps |
title | Predictive value of S100A4 in eosinophilic chronic rhinosinusitis with nasal polyps |
title_full | Predictive value of S100A4 in eosinophilic chronic rhinosinusitis with nasal polyps |
title_fullStr | Predictive value of S100A4 in eosinophilic chronic rhinosinusitis with nasal polyps |
title_full_unstemmed | Predictive value of S100A4 in eosinophilic chronic rhinosinusitis with nasal polyps |
title_short | Predictive value of S100A4 in eosinophilic chronic rhinosinusitis with nasal polyps |
title_sort | predictive value of s100a4 in eosinophilic chronic rhinosinusitis with nasal polyps |
topic | Surgery |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9663474/ https://www.ncbi.nlm.nih.gov/pubmed/36386522 http://dx.doi.org/10.3389/fsurg.2022.989489 |
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