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Conformational motions and ligand-binding underlying gating and regulation in IP(3)R channel

Inositol-1,4,5-trisphosphate receptors (IP(3)Rs) are activated by IP(3) and Ca(2+) and their gating is regulated by various intracellular messengers that finely tune the channel activity. Here, using single particle cryo-EM analysis we determined 3D structures of the nanodisc-reconstituted IP(3)R1 c...

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Detalles Bibliográficos
Autores principales:	Fan, Guizhen, Baker, Mariah R., Terry, Lara E., Arige, Vikas, Chen, Muyuan, Seryshev, Alexander B., Baker, Matthew L., Ludtke, Steven J., Yule, David I., Serysheva, Irina I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9663519/ https://www.ncbi.nlm.nih.gov/pubmed/36376291 http://dx.doi.org/10.1038/s41467-022-34574-1

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