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Reproductive risk factors associated with breast cancer in young women by molecular subtype

BACKGROUND: Few studies have examined detailed features of pregnancy and the postpartum period as potential risk factors for early onset breast cancer (BC) by molecular subtype. These data may have value for improving risk assessment and prevention. METHODS: We surveyed parous enrollees in the prosp...

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Autores principales: Ruddy, Kathryn J., Vierkant, Robert A., Jahan, Nusrat, Higgins, Alexandra, Partridge, Ann, Larson, Nicole, Radisky, Derek C., Couch, Fergus, Olson, Janet, Sherman, Mark E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9663520/
https://www.ncbi.nlm.nih.gov/pubmed/36375388
http://dx.doi.org/10.1016/j.breast.2022.11.004
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author Ruddy, Kathryn J.
Vierkant, Robert A.
Jahan, Nusrat
Higgins, Alexandra
Partridge, Ann
Larson, Nicole
Radisky, Derek C.
Couch, Fergus
Olson, Janet
Sherman, Mark E.
author_facet Ruddy, Kathryn J.
Vierkant, Robert A.
Jahan, Nusrat
Higgins, Alexandra
Partridge, Ann
Larson, Nicole
Radisky, Derek C.
Couch, Fergus
Olson, Janet
Sherman, Mark E.
author_sort Ruddy, Kathryn J.
collection PubMed
description BACKGROUND: Few studies have examined detailed features of pregnancy and the postpartum period as potential risk factors for early onset breast cancer (BC) by molecular subtype. These data may have value for improving risk assessment and prevention. METHODS: We surveyed parous enrollees in the prospective Mayo Clinic Breast Disease Registry (MCBDR) who had been diagnosed with BC at age <55 years between 2015 and 2020. Summary statistics were used to describe survey responses and reproductive risk factors by BC subtype (defined by estrogen/progesterone receptors and human epidermal growth factor receptor expression, nurse-abstracted from the medical record). Associations were assessed with Kruskal-Wallis and Chi-Square tests, followed by age-adjusted linear and logistic regression models. We compared results from this parous cohort to those from a separate cohort of nulliparous MCBDR participants with BC diagnosed at age <55 years. RESULTS: In 436 parous respondents with subtype data abstracted, we identified a higher frequency of BRCA1 mutation, earlier age at diagnosis, and lower BI in patients with triple negative BC. Comparing parous to nulliparous young women with breast cancer, the proportion with TNBC was larger in the latter (12.2% vs. 15.1%, p = 0.03). CONCLUSIONS: Early age at diagnosis and deleterious BRCA1 mutation were more frequent among TNBC patients. In addition, parous young women with TNBC had a lower BI than those with other BC subtypes, a hypothesis-generating finding that supports the need for additional research on the cycle of pregnancy-lactation-postpartum involution and BC etiology.
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spelling pubmed-96635202022-11-15 Reproductive risk factors associated with breast cancer in young women by molecular subtype Ruddy, Kathryn J. Vierkant, Robert A. Jahan, Nusrat Higgins, Alexandra Partridge, Ann Larson, Nicole Radisky, Derek C. Couch, Fergus Olson, Janet Sherman, Mark E. Breast Original Article BACKGROUND: Few studies have examined detailed features of pregnancy and the postpartum period as potential risk factors for early onset breast cancer (BC) by molecular subtype. These data may have value for improving risk assessment and prevention. METHODS: We surveyed parous enrollees in the prospective Mayo Clinic Breast Disease Registry (MCBDR) who had been diagnosed with BC at age <55 years between 2015 and 2020. Summary statistics were used to describe survey responses and reproductive risk factors by BC subtype (defined by estrogen/progesterone receptors and human epidermal growth factor receptor expression, nurse-abstracted from the medical record). Associations were assessed with Kruskal-Wallis and Chi-Square tests, followed by age-adjusted linear and logistic regression models. We compared results from this parous cohort to those from a separate cohort of nulliparous MCBDR participants with BC diagnosed at age <55 years. RESULTS: In 436 parous respondents with subtype data abstracted, we identified a higher frequency of BRCA1 mutation, earlier age at diagnosis, and lower BI in patients with triple negative BC. Comparing parous to nulliparous young women with breast cancer, the proportion with TNBC was larger in the latter (12.2% vs. 15.1%, p = 0.03). CONCLUSIONS: Early age at diagnosis and deleterious BRCA1 mutation were more frequent among TNBC patients. In addition, parous young women with TNBC had a lower BI than those with other BC subtypes, a hypothesis-generating finding that supports the need for additional research on the cycle of pregnancy-lactation-postpartum involution and BC etiology. Elsevier 2022-11-09 /pmc/articles/PMC9663520/ /pubmed/36375388 http://dx.doi.org/10.1016/j.breast.2022.11.004 Text en © 2022 Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Ruddy, Kathryn J.
Vierkant, Robert A.
Jahan, Nusrat
Higgins, Alexandra
Partridge, Ann
Larson, Nicole
Radisky, Derek C.
Couch, Fergus
Olson, Janet
Sherman, Mark E.
Reproductive risk factors associated with breast cancer in young women by molecular subtype
title Reproductive risk factors associated with breast cancer in young women by molecular subtype
title_full Reproductive risk factors associated with breast cancer in young women by molecular subtype
title_fullStr Reproductive risk factors associated with breast cancer in young women by molecular subtype
title_full_unstemmed Reproductive risk factors associated with breast cancer in young women by molecular subtype
title_short Reproductive risk factors associated with breast cancer in young women by molecular subtype
title_sort reproductive risk factors associated with breast cancer in young women by molecular subtype
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9663520/
https://www.ncbi.nlm.nih.gov/pubmed/36375388
http://dx.doi.org/10.1016/j.breast.2022.11.004
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