Channel HCN4 mutation R666Q associated with sporadic arrhythmia decreases channel electrophysiological function and increases protein degradation

Mutations in the hyperpolarization-activated nucleotide-gated channel 4 (HCN4) are known to be associated with arrhythmias in which QT prolongation (delayed ventricular repolarization) is rare. Here, we identified a HCN4 mutation, HCN4-R666Q, in two sporadic arrhythmia patients with sinus bradycardi...

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Detalles Bibliográficos
Autores principales: Wang, Hongrui, Wu, Tong, Huang, Zhuo, Huang, Jinghan, Geng, Ze, Cui, Bing, Yan, Yupeng, Zhang, Yu, Wang, Yibo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9663530/
https://www.ncbi.nlm.nih.gov/pubmed/36244448
http://dx.doi.org/10.1016/j.jbc.2022.102599

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