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Altered glycolysis triggers impaired mitochondrial metabolism and mTORC1 activation in diabetic β-cells

Chronic hyperglycaemia causes a dramatic decrease in mitochondrial metabolism and insulin content in pancreatic β-cells. This underlies the progressive decline in β-cell function in diabetes. However, the molecular mechanisms by which hyperglycaemia produces these effects remain unresolved. Using is...

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Detalles Bibliográficos
Autores principales:	Haythorne, Elizabeth, Lloyd, Matthew, Walsby-Tickle, John, Tarasov, Andrei I., Sandbrink, Jonas, Portillo, Idoia, Exposito, Raul Terron, Sachse, Gregor, Cyranka, Malgorzata, Rohm, Maria, Rorsman, Patrik, McCullagh, James, Ashcroft, Frances M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9663558/ https://www.ncbi.nlm.nih.gov/pubmed/36376280 http://dx.doi.org/10.1038/s41467-022-34095-x

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