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The role of dopamine and endocannabinoid systems in prefrontal cortex development: Adolescence as a critical period

The prefrontal cortex plays a central role in the control of complex cognitive processes including action control and decision making. It also shows a specific pattern of delayed maturation related to unique behavioral changes during adolescence and allows the development of adult cognitive processe...

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Autores principales: Peters, Kate Zara, Naneix, Fabien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9663658/
https://www.ncbi.nlm.nih.gov/pubmed/36389180
http://dx.doi.org/10.3389/fncir.2022.939235
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author Peters, Kate Zara
Naneix, Fabien
author_facet Peters, Kate Zara
Naneix, Fabien
author_sort Peters, Kate Zara
collection PubMed
description The prefrontal cortex plays a central role in the control of complex cognitive processes including action control and decision making. It also shows a specific pattern of delayed maturation related to unique behavioral changes during adolescence and allows the development of adult cognitive processes. The adolescent brain is extremely plastic and critically vulnerable to external insults. Related to this vulnerability, adolescence is also associated with the emergence of numerous neuropsychiatric disorders involving alterations of prefrontal functions. Within prefrontal microcircuits, the dopamine and the endocannabinoid systems have widespread effects on adolescent-specific ontogenetic processes. In this review, we highlight recent advances in our understanding of the maturation of the dopamine system and the endocannabinoid system in the prefrontal cortex during adolescence. We discuss how they interact with GABA and glutamate neurons to modulate prefrontal circuits and how they can be altered by different environmental events leading to long-term neurobiological and behavioral changes at adulthood. Finally, we aim to identify several future research directions to help highlight gaps in our current knowledge on the maturation of these microcircuits.
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spelling pubmed-96636582022-11-15 The role of dopamine and endocannabinoid systems in prefrontal cortex development: Adolescence as a critical period Peters, Kate Zara Naneix, Fabien Front Neural Circuits Neuroscience The prefrontal cortex plays a central role in the control of complex cognitive processes including action control and decision making. It also shows a specific pattern of delayed maturation related to unique behavioral changes during adolescence and allows the development of adult cognitive processes. The adolescent brain is extremely plastic and critically vulnerable to external insults. Related to this vulnerability, adolescence is also associated with the emergence of numerous neuropsychiatric disorders involving alterations of prefrontal functions. Within prefrontal microcircuits, the dopamine and the endocannabinoid systems have widespread effects on adolescent-specific ontogenetic processes. In this review, we highlight recent advances in our understanding of the maturation of the dopamine system and the endocannabinoid system in the prefrontal cortex during adolescence. We discuss how they interact with GABA and glutamate neurons to modulate prefrontal circuits and how they can be altered by different environmental events leading to long-term neurobiological and behavioral changes at adulthood. Finally, we aim to identify several future research directions to help highlight gaps in our current knowledge on the maturation of these microcircuits. Frontiers Media S.A. 2022-11-01 /pmc/articles/PMC9663658/ /pubmed/36389180 http://dx.doi.org/10.3389/fncir.2022.939235 Text en Copyright © 2022 Peters and Naneix. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Peters, Kate Zara
Naneix, Fabien
The role of dopamine and endocannabinoid systems in prefrontal cortex development: Adolescence as a critical period
title The role of dopamine and endocannabinoid systems in prefrontal cortex development: Adolescence as a critical period
title_full The role of dopamine and endocannabinoid systems in prefrontal cortex development: Adolescence as a critical period
title_fullStr The role of dopamine and endocannabinoid systems in prefrontal cortex development: Adolescence as a critical period
title_full_unstemmed The role of dopamine and endocannabinoid systems in prefrontal cortex development: Adolescence as a critical period
title_short The role of dopamine and endocannabinoid systems in prefrontal cortex development: Adolescence as a critical period
title_sort role of dopamine and endocannabinoid systems in prefrontal cortex development: adolescence as a critical period
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9663658/
https://www.ncbi.nlm.nih.gov/pubmed/36389180
http://dx.doi.org/10.3389/fncir.2022.939235
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