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Metformin can mitigate skeletal dysplasia caused by Pck2 deficiency

As an important enzyme for gluconeogenesis, mitochondrial phosphoenolpyruvate carboxykinase (PCK2) has further complex functions beyond regulation of glucose metabolism. Here, we report that conditional knockout of Pck2 in osteoblasts results in a pathological phenotype manifested as craniofacial ma...

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Detalles Bibliográficos
Autores principales:	Li, Zheng, Yue, Muxin, Heng, Boon Chin, Liu, Yunsong, Zhang, Ping, Zhou, Yongsheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9663691/ https://www.ncbi.nlm.nih.gov/pubmed/36376276 http://dx.doi.org/10.1038/s41368-022-00204-1

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