Symbiotic bacteria-dependent expansion of MR1-reactive T cells causes autoimmunity in the absence of Bcl11b

MHC class I-related protein 1 (MR1) is a metabolite-presenting molecule that restricts MR1-reactive T cells including mucosal-associated invariant T (MAIT) cells. In contrast to MAIT cells, the function of other MR1-restricted T cell subsets is largely unknown. Here, we report that mice in which a T...

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Detalles Bibliográficos
Autores principales: Shibata, Kensuke, Motozono, Chihiro, Nagae, Masamichi, Shimizu, Takashi, Ishikawa, Eri, Motooka, Daisuke, Okuzaki, Daisuke, Izumi, Yoshihiro, Takahashi, Masatomo, Fujimori, Nao, Wing, James B., Hayano, Takahide, Asai, Yoshiyuki, Bamba, Takeshi, Ogawa, Yoshihiro, Furutani-Seiki, Makoto, Shirai, Mutsunori, Yamasaki, Sho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9663695/
https://www.ncbi.nlm.nih.gov/pubmed/36376329
http://dx.doi.org/10.1038/s41467-022-34802-8

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