A Wolbachia factor for male killing in lepidopteran insects

Bacterial symbionts, such as Wolbachia species, can manipulate the sexual development and reproduction of their insect hosts. For example, Wolbachia infection induces male-specific death in the Asian corn borer Ostrinia furnacalis by targeting the host factor Masculinizer (Masc), an essential protei...

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Autores principales: Katsuma, Susumu, Hirota, Kanako, Matsuda-Imai, Noriko, Fukui, Takahiro, Muro, Tomohiro, Nishino, Kohei, Kosako, Hidetaka, Shoji, Keisuke, Takanashi, Hideki, Fujii, Takeshi, Arimura, Shin-ichi, Kiuchi, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9663696/
https://www.ncbi.nlm.nih.gov/pubmed/36376299
http://dx.doi.org/10.1038/s41467-022-34488-y
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author Katsuma, Susumu
Hirota, Kanako
Matsuda-Imai, Noriko
Fukui, Takahiro
Muro, Tomohiro
Nishino, Kohei
Kosako, Hidetaka
Shoji, Keisuke
Takanashi, Hideki
Fujii, Takeshi
Arimura, Shin-ichi
Kiuchi, Takashi
author_facet Katsuma, Susumu
Hirota, Kanako
Matsuda-Imai, Noriko
Fukui, Takahiro
Muro, Tomohiro
Nishino, Kohei
Kosako, Hidetaka
Shoji, Keisuke
Takanashi, Hideki
Fujii, Takeshi
Arimura, Shin-ichi
Kiuchi, Takashi
author_sort Katsuma, Susumu
collection PubMed
description Bacterial symbionts, such as Wolbachia species, can manipulate the sexual development and reproduction of their insect hosts. For example, Wolbachia infection induces male-specific death in the Asian corn borer Ostrinia furnacalis by targeting the host factor Masculinizer (Masc), an essential protein for masculinization and dosage compensation in lepidopteran insects. Here we identify a Wolbachia protein, designated Oscar, which interacts with Masc via its ankyrin repeats. Embryonic expression of Oscar inhibits Masc-induced masculinization and leads to male killing in two lepidopteran insects, O. furnacalis and the silkworm Bombyx mori. Our study identifies a mechanism by which Wolbachia induce male killing of host progeny.
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spelling pubmed-96636962022-11-15 A Wolbachia factor for male killing in lepidopteran insects Katsuma, Susumu Hirota, Kanako Matsuda-Imai, Noriko Fukui, Takahiro Muro, Tomohiro Nishino, Kohei Kosako, Hidetaka Shoji, Keisuke Takanashi, Hideki Fujii, Takeshi Arimura, Shin-ichi Kiuchi, Takashi Nat Commun Article Bacterial symbionts, such as Wolbachia species, can manipulate the sexual development and reproduction of their insect hosts. For example, Wolbachia infection induces male-specific death in the Asian corn borer Ostrinia furnacalis by targeting the host factor Masculinizer (Masc), an essential protein for masculinization and dosage compensation in lepidopteran insects. Here we identify a Wolbachia protein, designated Oscar, which interacts with Masc via its ankyrin repeats. Embryonic expression of Oscar inhibits Masc-induced masculinization and leads to male killing in two lepidopteran insects, O. furnacalis and the silkworm Bombyx mori. Our study identifies a mechanism by which Wolbachia induce male killing of host progeny. Nature Publishing Group UK 2022-11-14 /pmc/articles/PMC9663696/ /pubmed/36376299 http://dx.doi.org/10.1038/s41467-022-34488-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Katsuma, Susumu
Hirota, Kanako
Matsuda-Imai, Noriko
Fukui, Takahiro
Muro, Tomohiro
Nishino, Kohei
Kosako, Hidetaka
Shoji, Keisuke
Takanashi, Hideki
Fujii, Takeshi
Arimura, Shin-ichi
Kiuchi, Takashi
A Wolbachia factor for male killing in lepidopteran insects
title A Wolbachia factor for male killing in lepidopteran insects
title_full A Wolbachia factor for male killing in lepidopteran insects
title_fullStr A Wolbachia factor for male killing in lepidopteran insects
title_full_unstemmed A Wolbachia factor for male killing in lepidopteran insects
title_short A Wolbachia factor for male killing in lepidopteran insects
title_sort wolbachia factor for male killing in lepidopteran insects
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9663696/
https://www.ncbi.nlm.nih.gov/pubmed/36376299
http://dx.doi.org/10.1038/s41467-022-34488-y
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