Loss of GM-CSF-dependent instruction of alveolar macrophages in COVID-19 provides a rationale for inhaled GM-CSF treatment

GM-CSF promotes myelopoiesis and inflammation, and GM-CSF blockade is being evaluated as a treatment for COVID-19-associated hyperinflammation. Alveolar GM-CSF is, however, required for monocytes to differentiate into alveolar macrophages (AMs) that control alveolar homeostasis. By mapping cross-spe...

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Detalles Bibliográficos
Autores principales: Bosteels, Cedric, Van Damme, Karel F.A., De Leeuw, Elisabeth, Declercq, Jozefien, Maes, Bastiaan, Bosteels, Victor, Hoste, Levi, Naesens, Leslie, Debeuf, Nincy, Deckers, Julie, Cole, Basiel, Pardons, Marion, Weiskopf, Daniela, Sette, Alessandro, Weygaerde, Yannick Vande, Malfait, Thomas, Vandecasteele, Stefaan J., Demedts, Ingel K., Slabbynck, Hans, Allard, Sabine, Depuydt, Pieter, Van Braeckel, Eva, De Clercq, Jozefien, Martens, Liesbet, Dupont, Sam, Seurinck, Ruth, Vandamme, Niels, Haerynck, Filomeen, Roychowdhury, Debasish F., Vandekerckhove, Linos, Guilliams, Martin, Tavernier, Simon J., Lambrecht, Bart N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9663750/
https://www.ncbi.nlm.nih.gov/pubmed/36459994
http://dx.doi.org/10.1016/j.xcrm.2022.100833

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