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Streptolysin S targets the sodium-bicarbonate cotransporter NBCn1 to induce inflammation and cytotoxicity in human keratinocytes during Group A Streptococcal infection
Group A Streptococcus (GAS, Streptococcus pyogenes) is a Gram-positive human pathogen that employs several secreted and surface-bound virulence factors to manipulate its environment, allowing it to cause a variety of disease outcomes. One such virulence factor is Streptolysin S (SLS), a ribosomally-...
Autores principales: | Hammers, Daniel E., Donahue, Deborah L., Tucker, Zachary D., Ashfeld, Brandon L., Ploplis, Victoria A., Castellino, Francis J., Lee, Shaun W. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9663810/ https://www.ncbi.nlm.nih.gov/pubmed/36389147 http://dx.doi.org/10.3389/fcimb.2022.1002230 |
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