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Conformational state-dependent regulation of GABA(A) receptor diffusion and subsynaptic domains

The efficacy of GABAergic synapses relies on the number of postsynaptic GABA(A) receptors (GABA(A)Rs), which is regulated by a diffusion capture mechanism. Here, we report that the conformational state of GABA(A)Rs influences their membrane dynamics. Indeed, pharmacological and mutational manipulati...

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Detalles Bibliográficos
Autores principales:	Merlaud, Zaha, Marques, Xavier, Russeau, Marion, Saade, Ursula, Tostain, Maelys, Moutkine, Imane, Gielen, Marc, Corringer, Pierre-Jean, Lévi, Sabine
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9663900/ https://www.ncbi.nlm.nih.gov/pubmed/36388998 http://dx.doi.org/10.1016/j.isci.2022.105467

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