Successful pregnancy in a cystic fibrosis patient with a severe impairment of lung function receiving Elexacaftor-Tezacaftor-Ivacaftor

Before the arrival of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) modulators women with CF and impaired lung function were experiencing a high risk of complications and mortality during and the years after pregnancy. The arrival of the highly efficient CFTR modulator, Elexacaftor-Teza...

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Autores principales: Balmpouzis, Zisis, Faure van Rossum, Annabelle, Baud, David, Panchaud, Alice, Mitropoulou, Georgia, Mazza Stalder, Jesica, Koutsokera, Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664010/
https://www.ncbi.nlm.nih.gov/pubmed/36386288
http://dx.doi.org/10.1016/j.rmcr.2022.101776
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author Balmpouzis, Zisis
Faure van Rossum, Annabelle
Baud, David
Panchaud, Alice
Mitropoulou, Georgia
Mazza Stalder, Jesica
Koutsokera, Angela
author_facet Balmpouzis, Zisis
Faure van Rossum, Annabelle
Baud, David
Panchaud, Alice
Mitropoulou, Georgia
Mazza Stalder, Jesica
Koutsokera, Angela
author_sort Balmpouzis, Zisis
collection PubMed
description Before the arrival of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) modulators women with CF and impaired lung function were experiencing a high risk of complications and mortality during and the years after pregnancy. The arrival of the highly efficient CFTR modulator, Elexacaftor-Tezacaftor-Ivacaftor (ETI) resulted in an improvement of lung function, quality of life and fertility. Here we report a case of successful pregnancy and uncomplicated delivery for a CF patient with severely impaired lung function receiving ETI prior to conception.
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spelling pubmed-96640102022-11-15 Successful pregnancy in a cystic fibrosis patient with a severe impairment of lung function receiving Elexacaftor-Tezacaftor-Ivacaftor Balmpouzis, Zisis Faure van Rossum, Annabelle Baud, David Panchaud, Alice Mitropoulou, Georgia Mazza Stalder, Jesica Koutsokera, Angela Respir Med Case Rep Case Report Before the arrival of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) modulators women with CF and impaired lung function were experiencing a high risk of complications and mortality during and the years after pregnancy. The arrival of the highly efficient CFTR modulator, Elexacaftor-Tezacaftor-Ivacaftor (ETI) resulted in an improvement of lung function, quality of life and fertility. Here we report a case of successful pregnancy and uncomplicated delivery for a CF patient with severely impaired lung function receiving ETI prior to conception. Elsevier 2022-11-08 /pmc/articles/PMC9664010/ /pubmed/36386288 http://dx.doi.org/10.1016/j.rmcr.2022.101776 Text en © 2022 The Authors. Published by Elsevier Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Balmpouzis, Zisis
Faure van Rossum, Annabelle
Baud, David
Panchaud, Alice
Mitropoulou, Georgia
Mazza Stalder, Jesica
Koutsokera, Angela
Successful pregnancy in a cystic fibrosis patient with a severe impairment of lung function receiving Elexacaftor-Tezacaftor-Ivacaftor
title Successful pregnancy in a cystic fibrosis patient with a severe impairment of lung function receiving Elexacaftor-Tezacaftor-Ivacaftor
title_full Successful pregnancy in a cystic fibrosis patient with a severe impairment of lung function receiving Elexacaftor-Tezacaftor-Ivacaftor
title_fullStr Successful pregnancy in a cystic fibrosis patient with a severe impairment of lung function receiving Elexacaftor-Tezacaftor-Ivacaftor
title_full_unstemmed Successful pregnancy in a cystic fibrosis patient with a severe impairment of lung function receiving Elexacaftor-Tezacaftor-Ivacaftor
title_short Successful pregnancy in a cystic fibrosis patient with a severe impairment of lung function receiving Elexacaftor-Tezacaftor-Ivacaftor
title_sort successful pregnancy in a cystic fibrosis patient with a severe impairment of lung function receiving elexacaftor-tezacaftor-ivacaftor
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664010/
https://www.ncbi.nlm.nih.gov/pubmed/36386288
http://dx.doi.org/10.1016/j.rmcr.2022.101776
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