Activation of innate-adaptive immune machinery by poly(I:C) exposes a therapeutic vulnerability to prevent relapse in stroma-rich colon cancer

OBJECTIVE: Stroma-rich tumours represent a poor prognostic subtype in stage II/III colon cancer (CC), with high relapse rates and limited response to standard adjuvant chemotherapy. DESIGN: To address the lack of efficacious therapeutic options for patients with stroma-rich CC, we stratified our hum...

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Detalles Bibliográficos
Autores principales: Corry, Shania M, McCorry, Amy MB, Lannagan, Tamsin RM, Leonard, Niamh A, Fisher, Natalie C, Byrne, Ryan M, Tsantoulis, Petros, Cortes-Lavaud, Xabier, Amirkhah, Raheleh, Redmond, Keara L, McCooey, Aoife J, Malla, Sudhir B, Rogan, Emily, Sakhnevych, Svetlana, Gillespie, Michael A, White, Mark, Richman, Susan D, Jackstadt, Rene-Filip, Campbell, Andrew D, Maguire, Sarah, McDade, Simon S, Longley, Daniel B, Loughrey, Maurice B, Coleman, Helen G, Kerr, Emma M, Tejpar, Sabine, Maughan, Timothy, Leedham, Simon J, Small, Donna M, Ryan, Aideen E, Sansom, Owen J, Lawler, Mark, Dunne, Philip D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Colon
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664095/
https://www.ncbi.nlm.nih.gov/pubmed/35477539
http://dx.doi.org/10.1136/gutjnl-2021-326183

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