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Distinct immune-effector and metabolic profile of CD8(+) T cells in patients with autoimmune polyarthritis induced by therapy with immune checkpoint inhibitors
OBJECTIVES: Rheumatic immune-related adverse events (irAE) such as (poly)arthritis in patients undergoing immune checkpoint inhibitor (ICI) treatment pose a major clinical challenge. ICI therapy improves CD8(+) T cell (CD8) function, but CD8 contributes to chronic inflammation in autoimmune arthriti...
Autores principales: | Benesova, Karolina, Kraus, Franziska Viktoria, Carvalho, Rui A, Lorenz, Holger, Hörth, Christian H, Günther, Janine, Klika, Karel D, Graf, Jürgen, Diekmann, Leonore, Schank, Timo, Christopoulos, Petros, Hassel, Jessica C, Lorenz, Hanns-Martin, Souto-Carneiro, Margarida |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664113/ https://www.ncbi.nlm.nih.gov/pubmed/35922125 http://dx.doi.org/10.1136/ard-2022-222451 |
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