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FAD-deficient P187S mutation of NAD(P)H:quinone oxidoreductase 1 (NQO1*2) binds and accelerates β-amyloid aggregation

Alzheimer’s disease (AD) is one of the most prominent neurodegenerative diseases. Results from animal and cellular models suggest that FAD-deficient forms of NAD(P)H quinone oxidoreductase 1 (NQO1) may accelerate the aggregation of Alzheimer’s amyloid-β peptide (Aβ(1-42)). Here, we examined in vitro...

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Detalles Bibliográficos
Autores principales:	Panja, Sudipta, Siegel, David, Camandola, Simonetta, de Cabo, Rafael, Ross, David, Mallela, Krishna M.G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2022
Materias:	Aging
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664297/ https://www.ncbi.nlm.nih.gov/pubmed/36281795 http://dx.doi.org/10.1042/BSR20220643

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