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Efficacy of Two-phase Treatment Regimen for Rhino-facial Entomophthoromycosis: Our Experience and Review of Literature

This paper reviews our institutional experience in the management of rhino-facial entomophthoromycosis, a rare subcutaneous fungal infection. We adopt a fixed two-phase protocol comprising an initial ‘intensive phase’ (two-drug regimen) followed by an ‘eradication phase’ (monotherapy). We present fi...

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Autores principales: Chadaram, Srinivas, Chappity, Preetam, Hallur, Vinaykumar, Sharma, Prity, Pradeep, Pradhan, Parida, Pradipta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: OMJ 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664314/
https://www.ncbi.nlm.nih.gov/pubmed/36458237
http://dx.doi.org/10.5001/omj.2022.29
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author Chadaram, Srinivas
Chappity, Preetam
Hallur, Vinaykumar
Sharma, Prity
Pradeep, Pradhan
Parida, Pradipta
author_facet Chadaram, Srinivas
Chappity, Preetam
Hallur, Vinaykumar
Sharma, Prity
Pradeep, Pradhan
Parida, Pradipta
author_sort Chadaram, Srinivas
collection PubMed
description This paper reviews our institutional experience in the management of rhino-facial entomophthoromycosis, a rare subcutaneous fungal infection. We adopt a fixed two-phase protocol comprising an initial ‘intensive phase’ (two-drug regimen) followed by an ‘eradication phase’ (monotherapy). We present five patients treated between May 2013 and May 2020 in our institution who were subjected to the mentioned protocol. All five patients received six months of supersaturated potassium iodide solution and itraconazole, followed by four months of monotherapy with only supersaturated potassium iodide solution. All patients responded well to the treatment and were disease-free on follow-up of a minimum two years post-treatment. We recommend this procedure for all typical cases of entomophthoromycosis and suggest avoiding surgical intervention which may disseminate the fungus and delay response to treatment.
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spelling pubmed-96643142022-11-30 Efficacy of Two-phase Treatment Regimen for Rhino-facial Entomophthoromycosis: Our Experience and Review of Literature Chadaram, Srinivas Chappity, Preetam Hallur, Vinaykumar Sharma, Prity Pradeep, Pradhan Parida, Pradipta Oman Med J Case Reports This paper reviews our institutional experience in the management of rhino-facial entomophthoromycosis, a rare subcutaneous fungal infection. We adopt a fixed two-phase protocol comprising an initial ‘intensive phase’ (two-drug regimen) followed by an ‘eradication phase’ (monotherapy). We present five patients treated between May 2013 and May 2020 in our institution who were subjected to the mentioned protocol. All five patients received six months of supersaturated potassium iodide solution and itraconazole, followed by four months of monotherapy with only supersaturated potassium iodide solution. All patients responded well to the treatment and were disease-free on follow-up of a minimum two years post-treatment. We recommend this procedure for all typical cases of entomophthoromycosis and suggest avoiding surgical intervention which may disseminate the fungus and delay response to treatment. OMJ 2022-11-30 /pmc/articles/PMC9664314/ /pubmed/36458237 http://dx.doi.org/10.5001/omj.2022.29 Text en The OMJ is Published Bimonthly and Copyrighted 2022 by the OMSB. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC) 4.0 License. http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle Case Reports
Chadaram, Srinivas
Chappity, Preetam
Hallur, Vinaykumar
Sharma, Prity
Pradeep, Pradhan
Parida, Pradipta
Efficacy of Two-phase Treatment Regimen for Rhino-facial Entomophthoromycosis: Our Experience and Review of Literature
title Efficacy of Two-phase Treatment Regimen for Rhino-facial Entomophthoromycosis: Our Experience and Review of Literature
title_full Efficacy of Two-phase Treatment Regimen for Rhino-facial Entomophthoromycosis: Our Experience and Review of Literature
title_fullStr Efficacy of Two-phase Treatment Regimen for Rhino-facial Entomophthoromycosis: Our Experience and Review of Literature
title_full_unstemmed Efficacy of Two-phase Treatment Regimen for Rhino-facial Entomophthoromycosis: Our Experience and Review of Literature
title_short Efficacy of Two-phase Treatment Regimen for Rhino-facial Entomophthoromycosis: Our Experience and Review of Literature
title_sort efficacy of two-phase treatment regimen for rhino-facial entomophthoromycosis: our experience and review of literature
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664314/
https://www.ncbi.nlm.nih.gov/pubmed/36458237
http://dx.doi.org/10.5001/omj.2022.29
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