DNA-mediated proteolysis by neutrophil elastase enhances binding activities of the HMGB1 protein

Neutrophil extracellular traps (NETs) are produced through ejection of genomic DNA by neutrophils into extracellular space and serve as a weapon to fight against pathogens. Neutrophil elastase, a serine protease loaded on NETs, attacks and kills pathogens, while extracellular high-mobility-group-box...

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Detalles Bibliográficos
Autores principales: Wang, Xi, Mayorga-Flores, Marlen, Bien, Karina G., Bailey, Aaron O., Iwahara, Junji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664404/
https://www.ncbi.nlm.nih.gov/pubmed/36220391
http://dx.doi.org/10.1016/j.jbc.2022.102577

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