Elucidating the genetic architecture of DNA methylation to identify promising molecular mechanisms of disease

DNA methylation commonly occurs at cytosine-phosphate-guanine sites (CpGs) that can serve as biomarkers for many diseases. We analyzed whole genome sequencing data to identify DNA methylation quantitative trait loci (mQTLs) in 4126 Framingham Heart Study participants. Our mQTL mapping identified 94,...

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Detalles Bibliográficos
Autores principales: Ma, Jiantao, Joehanes, Roby, Liu, Chunyu, Keshawarz, Amena, Hwang, Shih-Jen, Bui, Helena, Tejada, Brandon, Sooda, Meera, Munson, Peter J., Demirkale, Cumhur Y., Courchesne, Paul, Heard-Costa, Nancy L., Pitsillides, Achilleas N., Feolo, Mike, Sharopova, Nataliya, Vasan, Ramachandran S., Huan, Tianxiao, Levy, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664436/
https://www.ncbi.nlm.nih.gov/pubmed/36380121
http://dx.doi.org/10.1038/s41598-022-24100-0

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