Cargando…

Genome-wide CRISPR screen reveals v-ATPase as a drug target to lower levels of ALS protein ataxin-2

Mutations in the ataxin-2 gene (ATXN2) cause the neurodegenerative disorders amyotrophic lateral sclerosis (ALS) and spinocerebellar ataxia type 2 (SCA2). A therapeutic strategy using antisense oligonucleotides targeting ATXN2 has entered clinical trial in humans. Additional ways to decrease ataxin-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Garam, Nakayama, Lisa, Blum, Jacob A., Akiyama, Tetsuya, Boeynaems, Steven, Chakraborty, Meenakshi, Couthouis, Julien, Tassoni-Tsuchida, Eduardo, Rodriguez, Caitlin M., Bassik, Michael C., Gitler, Aaron D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664452/ https://www.ncbi.nlm.nih.gov/pubmed/36288714 http://dx.doi.org/10.1016/j.celrep.2022.111508

Ejemplares similares

These violent repeats have violent extends
por: Couthouis, Julien, et al.
Publicado: (2018)

Model Organisms Reveal Insight into Human Neurodegenerative Disease: Ataxin-2 Intermediate-Length Polyglutamine Expansions Are a Risk Factor for ALS
por: Bonini, Nancy M., et al.
Publicado: (2011)

Targeted Exon Capture and Sequencing in Sporadic Amyotrophic Lateral Sclerosis
por: Couthouis, Julien, et al.
Publicado: (2014)

CRISPR-Cas9 screens in human cells and primary neurons identify modifiers of C9orf72 dipeptide repeat protein toxicity
por: Kramer, Nicholas J., et al.
Publicado: (2018)

Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS
por: Elden, Andrew C., et al.
Publicado: (2010)

Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model
por: Guttenplan, Kevin A., et al.
Publicado: (2020)

Therapeutic reduction of ataxin 2 extends lifespan and reduces pathology in TDP-43 mice
por: Becker, Lindsay A., et al.
Publicado: (2017)

FOX-2 Dependent Splicing of Ataxin-2 Transcript Is Affected by Ataxin-1 Overexpression
por: Welzel, Franziska, et al.
Publicado: (2012)

De Novo Mutations in Ataxin-2 Gene and ALS Risk
por: Laffita-Mesa, José Miguel, et al.
Publicado: (2013)

Mitigating a TDP-43 proteinopathy by targeting ataxin-2 using RNA-targeting CRISPR effector proteins
por: Zeballos C, M. Alejandra, et al.
Publicado: (2023)

Mitigating a TDP-43 proteinopathy by targeting ataxin-2 using RNA-targeting CRISPR effector proteins
por: Zeballos C., M. Alejandra, et al.
Publicado: (2023)

Cracking the cryptic code in amyotrophic lateral sclerosis and frontotemporal dementia: Towards therapeutic targets and biomarkers
por: Akiyama, Tetsuya, et al.
Publicado: (2022)

Nucleocytoplasmic Shuttling Activity of Ataxin-3
por: Macedo-Ribeiro, Sandra, et al.
Publicado: (2009)

dAtaxin-2 Mediates Expanded Ataxin-1-Induced Neurodegeneration in a Drosophila Model of SCA1
por: Al-Ramahi, Ismael, et al.
Publicado: (2007)

Aurora B-dependent phosphorylation of Ataxin-10 promotes the interaction between Ataxin-10 and Plk1 in cytokinesis
por: Tian, Jie, et al.
Publicado: (2015)

Universal RNAi Triggers for the Specific Inhibition of Mutant Huntingtin, Atrophin-1, Ataxin-3, and Ataxin-7 Expression
por: Kotowska-Zimmer, Anna, et al.
Publicado: (2019)

LRRK2 modifies α-syn pathology and spread in mouse models and human neurons
por: Bieri, Gregor, et al.
Publicado: (2019)

Symmetric dimethylation of poly-GR correlates with disease duration in C9orf72 FTLD and ALS and reduces poly-GR phase separation and toxicity
por: Gittings, Lauren M., et al.
Publicado: (2019)

2169: Hydrogen bonding and water accessibility changes upon expansion of PolyQ tracts in ataxin-2 and ataxin-3
por: Wen, Jingran, et al.
Publicado: (2018)

Conformational Behavior and Aggregation of Ataxin-3 in SDS
por: Saunders, Helen M., et al.
Publicado: (2013)

Stabilization and Degradation Mechanisms of Cytoplasmic Ataxin-1
por: Kohiyama, Mayumi F., et al.
Publicado: (2016)

PINK1 and Ataxin-2 as modifiers of growth
por: Sen, Nesli E., et al.
Publicado: (2017)

Epigenetic control of ataxin‐1 in multiple sclerosis
por: Ma, Qin, et al.
Publicado: (2022)

Mouse Ataxin-3 Functional Knock-Out Model
por: Switonski, Pawel M., et al.
Publicado: (2010)

Characterization of the Conformational Fluctuations in the Josephin Domain of Ataxin-3
por: Sanfelice, Domenico, et al.
Publicado: (2014)

Intercellular Propagation and Aggregate Seeding of Mutant Ataxin-1
por: Huang, Haoyang, et al.
Publicado: (2021)

Ataxin-2 is essential for cytoskeletal dynamics and neurodevelopment in Drosophila
por: del Castillo, Urko, et al.
Publicado: (2021)

Intracellular dynamics of Ataxin-2 in the human brains with normal and frontotemporal lobar degeneration with TDP-43 inclusions
por: Watanabe, Ryohei, et al.
Publicado: (2020)

Genome-Wide Screen for Modifiers of Ataxin-3 Neurodegeneration in Drosophila
por: Bilen, Julide, et al.
Publicado: (2007)

Basal and stress-induced Hsp70 are modulated by ataxin-3
por: Reina, Christopher P., et al.
Publicado: (2012)

Dissociated Fear and Spatial Learning in Mice with Deficiency of Ataxin-2
por: Huynh, Duong P., et al.
Publicado: (2009)

Ataxin-3 Is a Multivalent Ligand for the Parkin Ubl Domain
por: Bai, Jane J., et al.
Publicado: (2013)

Requirement for Zebrafish Ataxin-7 in Differentiation of Photoreceptors and Cerebellar Neurons
por: Yanicostas, Constantin, et al.
Publicado: (2012)

Polyglutamine Tract Expansion Increases S-Nitrosylation of Huntingtin and Ataxin-1
por: Ni, Chun-Lun, et al.
Publicado: (2016)

Ataxin-3 promotes genome integrity by stabilizing Chk1
por: Tu, Yingfeng, et al.
Publicado: (2017)

Ataxin-2: From RNA Control to Human Health and Disease
por: Ostrowski, Lauren A., et al.
Publicado: (2017)

Ataxin-2 gene: a powerful modulator of neurological disorders
por: Laffita-Mesa, Jose Miguel, et al.
Publicado: (2021)

The Deubiquitinating Enzyme Ataxin-3 Regulates Ciliogenesis and Phagocytosis in the Retina
por: Toulis, Vasileios, et al.
Publicado: (2020)

Large-Scale Screen for Modifiers of Ataxin-3-Derived Polyglutamine-Induced Toxicity in Drosophila
por: Voßfeldt, Hannes, et al.
Publicado: (2012)

Histone deacetylase-3 interacts with ataxin-7 and is altered in a spinocerebellar ataxia type 7 mouse model
por: Duncan, Carlotta E, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_nuo64s8a74qoqhgk41j6jd11gb